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WFRF:(Miyashita Chihiro)
 

Sökning: WFRF:(Miyashita Chihiro) > DNA methylation cha...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005710naa a2200733 4500
001oai:lup.lub.lu.se:728be5ae-c0a1-42d4-920b-0c17c838381c
003SwePub
008211008s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147885973
0247 a https://lup.lub.lu.se/record/728be5ae-c0a1-42d4-920b-0c17c838381c2 URI
0247 a https://doi.org/10.1016/j.envres.2021.1120932 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1478859732 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lozano, Manuelu University of Valencia4 aut
2451 0a DNA methylation changes associated with prenatal mercury exposure : A meta-analysis of prospective cohort studies from PACE consortium
264 1b Elsevier BV,c 2022
520 a Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10−4, p-value = 5.87 × 10−5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10−5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (β = 0.002, p-value = 4.81 × 10−7) in GRK1 and cg02212000 (β = −0.001, p-value = 8.13 × 10−7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a ALSPAC
653 a DNA methylation
653 a HELIX study
653 a Mercury
653 a Methylmercury
653 a PACE
653 a Prenatal exposure
7001 a Yousefi, Paulu University of Bristol4 aut
7001 a Broberg, Karinu Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)kgen-kbr
7001 a Soler-Blasco, Raquelu University of Valencia4 aut
7001 a Miyashita, Chihirou Hokkaido University4 aut
7001 a Pesce, Giancarlou Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay4 aut
7001 a Kim, Woo Jinu Kangwon National University4 aut
7001 a Rahman, Mohammadu Harvard Pilgrim Health Care Institute,Harvard Medical School4 aut
7001 a Bakulski, Kelly M.u University of Michigan4 aut
7001 a Haug, Line S.u Norwegian Institute of Public Health4 aut
7001 a Ikeda-Araki, Atsukou Hokkaido University4 aut
7001 a Huel, Guyu Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay4 aut
7001 a Park, Jaehyunu Seoul National University4 aut
7001 a Relton, Carolineu University of Bristol4 aut
7001 a Vrijheid, Martineu Centre for Research in Environmental Epidemiology,Pompeu Fabra University4 aut
7001 a Rifas-Shiman, Sherylu Harvard Medical School,Harvard Pilgrim Health Care Institute4 aut
7001 a Oken, Emilyu Harvard Medical School,Harvard Pilgrim Health Care Institute4 aut
7001 a Dou, John F.u University of Michigan4 aut
7001 a Kishi, Reikou Hokkaido University4 aut
7001 a Gutzkow, Kristine B.u Norwegian Institute of Public Health4 aut
7001 a Annesi-Maesano, Isabellau University of Montpellier4 aut
7001 a Won, Sunghou Seoul National University4 aut
7001 a Hivert, Marie Franceu Massachusetts General Hospital4 aut
7001 a Fallin, M. Danieleu Johns Hopkins Bloomberg School of Public Health4 aut
7001 a Vafeiadi, Marinau University of Crete Medical School4 aut
7001 a Ballester, Ferranu University of Valencia4 aut
7001 a Bustamante, Marionau Centre for Research in Environmental Epidemiology,Pompeu Fabra University4 aut
7001 a Llop, Sabrinau University of Valencia,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7102 a University of Valenciab University of Bristol4 org
7730 t Environmental Researchd : Elsevier BVg 204q 204x 0013-9351x 1096-0953
8564 u http://dx.doi.org/10.1016/j.envres.2021.112093x freey FULLTEXT
8564 u https://doi.org/10.1016/j.envres.2021.112093
8564 8u https://lup.lub.lu.se/record/728be5ae-c0a1-42d4-920b-0c17c838381c
8564 8u https://doi.org/10.1016/j.envres.2021.112093
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147885973

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