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  • Andreucci, Alessandro (author)

Cadmium may impair prostate function as measured by Prostate Specific Antigen in semen: a cross-sectional study among European and Inuit men.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1b3b3484-5353-405a-83b4-01aa25107a53
  • https://lup.lub.lu.se/record/5145128URI
  • https://doi.org/10.1016/j.reprotox.2015.01.010DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log (ß)= -0.121, 95% Confidence Interval (CI):-0.213; -0.029, P=0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log (ß)=-0.231, 95% CI:-0.363; -0.098, P=0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mocevic, Emina (author)
  • Jönsson, Bo ALund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)kir-agi (author)
  • Giwercman, YvonneLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-ylu (author)
  • Toft, Gunnar (author)
  • Lundh, ThomasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-tlu (author)
  • Bizzaro, Davide (author)
  • Specht, Ina Olmer (author)
  • Bonde, Jens Peter (author)
  • Avdelningen för arbets- och miljömedicinInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Reproductive Toxicology: Elsevier BV53:Feb 3, s. 33-381873-17080890-6238

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