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Sökning: WFRF:(Mohseni Shahin docent 1978 ) > (2019) > The Association Bet...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004702nam a2200469 4500
001oai:DiVA.org:oru-73256
003SwePub
008190321s2019 | |||||||||||000 ||eng|
020 a 9789175292779q print
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-732562 URI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
100a Ahl, Rebecka,d 1987-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)raal
2451 0a The Association Between Beta-Blockade and Clinical Outcomes in the Context of Surgical and Traumatic Stress
264 1a Örebro :b Örebro University,c 2019
300 a 96 s.
338 a print2 rdacarrier
490a Örebro Studies in Medicine,x 1652-4063 ;v 194
520 a Traumatic injury and major abdominal surgery are areas in general surgery associated with high rates of morbidity and mortality. The overall colorectal cancer surgery mortality rate is around 4%, with that for emergency surgery more than twice as high as for planned. Surgical morbidity varies between 25% and 45%. Around half of trauma patients develop low mood. In one quarter of patients this becomes permanent. Depression is known to impede physical rehabilitation and recovery. The onset of physiological stress, driven by adrenergic hyperactivity following traumatic and surgical injury is hypothesized to contribute to these adverse outcomes. Interest has therefore been sparked into blocking adrenergic receptor activation.Papers I and II investigated the role of beta-blocker therapy in preventing post-traumatic depression following severe traumatic brain injury (Paper I) and severe extracranial injury (Paper II). The Karolinska University Hospital Trauma Registry was used to identify patients admitted between 2007 and 2011. In Paper I (n = 545), patients on pre-injury beta-blocker therapy were matched to beta-blocker naïve patients with equivalent injury burden. Results revealed that beta-blocked patients exhibited a 60% reduced risk of needing antidepressant therapy within one year of trauma. In Paper II (n = 596), the lack of beta-blocker use before extracranial trauma was linked to a three-fold increase in the risk of antidepressant initiation.Papers III-V explored the role of pre-operative beta-blocker therapy in patients undergoing surgery for colorectal cancer between 2007 and 2016, identified using the nationwide Swedish Colorectal Cancer Registry. Paper III (n = 3,187) identified a 69% reduction in the risk of 30-day mortality in beta-blocked patients. Paper IV (n = 22,337) outlined long-term survival benefits for patients on beta-blocker therapy prior to undergoing elective surgery for colon cancer. Beta-blocked patients showed a risk reduction of 42% for 1-year all-cause mortality and 18% for 5-year cancerspecific mortality. Similarly, patients on beta-blocker therapy who underwent surgery for rectal cancer demonstrated improved survival up to one year after surgery with a risk reduction of 57% and a reduction in anastomotic failure and infectious complications in Paper V (n = 11,966).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a Beta-blocker therapy
653 a adrenergic hyperactivity
653 a physiological stress
653 a trauma
653 a depression
653 a colorectal cancer
653 a complications
653 a mortality
700a Mohseni, Shahin,c docent,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län4 ths0 (Swepub:oru)snmi
700a Riddez, Louis,c docentu Karolinska Institutet, Stockholm; Karolinska Sjukhuset, Solna4 ths
700a Wallin, Göran,c adjungerad professor,d 1952-u Örebro universitet,Institutionen för medicinska vetenskaper4 ths0 (Swepub:oru)gwn
700a Ljungqvist, Olle,c professor,d 1954-u Örebro universitet,Institutionen för medicinska vetenskaper4 ths0 (Swepub:oru)olt
700a Tilsed, Jonathan,c professoru Hull & East Yorkshire Hospitals NHS4 opn
710a Örebro universitetb Institutionen för medicinska vetenskaper4 org
856u https://oru.diva-portal.org/smash/get/diva2:1297762/PREVIEW01.pngx Previewy preview image
856u https://oru.diva-portal.org/smash/get/diva2:1297762/COVER01.pdfy cover
856u https://oru.diva-portal.org/smash/get/diva2:1297762/SPIKBLAD01.pdfy spikblad
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73256

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