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Associations among ...
Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project
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- Bauckneht, Matteo (author)
- IRCCS Osped Policlin San Martino, Italy
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- Chincarini, Andrea (author)
- Natl Inst Nucl Phys INFN, Italy
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- Brendel, Matthias (author)
- Ludwig Maximilians Univ Munchen, Germany
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- Rominger, Axel (author)
- Ludwig Maximilians Univ Munchen, Germany; Univ Hosp Bern, Switzerland
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- Beyer, Leonie (author)
- Ludwig Maximilians Univ Munchen, Germany
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- Bruffaerts, Rose (author)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium; Hasselt Univ, Belgium
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- Vandenberghe, Rik (author)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium
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- Kramberger, Milica G. (author)
- Univ Med Ctr Ljubljana, Slovenia; Univ Ljubljana, Slovenia
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- Trost, Maja (author)
- Univ Med Ctr Ljubljana, Slovenia; Univ Ljubljana, Slovenia
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- Garibotto, Valentina (author)
- Univ Geneva, Switzerland; Univ Geneva, Switzerland
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- Nicastro, Nicolas (author)
- Geneva Univ Hosp, Switzerland; Univ Cambridge, England
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- Frisoni, Giovanni B. (author)
- Geneva Univ Hosp, Switzerland
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- Lemstra, Afina W. (author)
- Vrije Univ Amsterdam, Netherlands
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- Berckel, Bart N. M. (author)
- Vrije Univ Amsterdam, Netherlands
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- Pilotto, Andrea (author)
- Univ Brescia, Italy; Isidoro Hosp, Italy
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- Padovani, Alessandro (author)
- Univ Brescia, Italy
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- Ochoa-Figueroa, Miguel A. (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping,Region Östergötland, Fysiologiska kliniken US
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- Davidsson, Anette (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
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- Camacho, Valle (author)
- Univ Autonoma Barcelona, Spain
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- Peira, Enrico (author)
- Natl Inst Nucl Phys INFN, Italy; Univ Genoa, Italy
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- Arnaldi, Dario (author)
- Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
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- Pardini, Matteo (author)
- Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
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- Donegani, Maria Isabella (author)
- Univ Genoa, Italy
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- Raffa, Stefano (author)
- Univ Genoa, Italy
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- Miceli, Alberto (author)
- Univ Genoa, Italy
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- Sambuceti, Gianmario (author)
- IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy
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- Aarsland, Dag (author)
- Karolinska Institutet
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- Nobili, Flavio (author)
- Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
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- Morbelli, Silvia (author)
- IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy
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(creator_code:org_t)
- 2021-02-02
- 2021
- English.
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In: Alzheimer's & Dementia. - : WILEY. - 1552-5260 .- 1552-5279. ; 17:8, s. 1277-1286
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Introduction We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- biomarkers; cognitive reserve; dementia with Lewy bodies; fluorodeoxyglucose positron emission tomography
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bauckneht, Matte ...
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Chincarini, Andr ...
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Brendel, Matthia ...
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Rominger, Axel
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Beyer, Leonie
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Bruffaerts, Rose
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Vandenberghe, Ri ...
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Kramberger, Mili ...
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Trost, Maja
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Garibotto, Valen ...
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Nicastro, Nicola ...
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Frisoni, Giovann ...
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Lemstra, Afina W ...
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Berckel, Bart N. ...
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Pilotto, Andrea
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Padovani, Alessa ...
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Ochoa-Figueroa, ...
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Davidsson, Anett ...
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Camacho, Valle
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Peira, Enrico
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Arnaldi, Dario
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Pardini, Matteo
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Donegani, Maria ...
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Raffa, Stefano
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Miceli, Alberto
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Sambuceti, Gianm ...
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Aarsland, Dag
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Nobili, Flavio
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Morbelli, Silvia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Linköping University
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Karolinska Institutet