WFRF:(Morentin Gutierrez Pablo)
Sökning: WFRF:(Morentin Gutierrez Pablo) > (2012) > Design and optimiza...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02660naa a2200517 4500 | |
| 001 | oai:DiVA.org:uu-211228 | |
| 003 | SwePub | |
| 008 | 131121s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2112282 URI |
| 024 | 7 | a https://doi.org/10.1021/jm301296t2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Barlind, Jonas G4 aut |
| 245 | 1 0 | a Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687) |
| 264 | c 2012-11-21 | |
| 264 | 1 | b American Chemical Society (ACS),c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and DMPK properties combined with a low predicted dose in man. Rational design and optimization of this series led to the discovery of compound 30 (AZD7687), which met the project objectives for potency, selectivity, in particular over ACAT1, solubility, and preclinical PK profiles. This compound showed the anticipated excellent pharmacokinetic properties in human volunteers. | |
| 700 | 1 | a Bauer, Udo A4 aut |
| 700 | 1 | a Birch, Alan M4 aut |
| 700 | 1 | a Birtles, Susan4 aut |
| 700 | 1 | a Buckett, Linda K4 aut |
| 700 | 1 | a Butlin, Roger J4 aut |
| 700 | 1 | a Davies, Robert D M4 aut |
| 700 | 1 | a Eriksson, Jan Wu Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut0 (Swepub:uu)janer909 |
| 700 | 1 | a Hammond, Clare D4 aut |
| 700 | 1 | a Hovland, Ragnar4 aut |
| 700 | 1 | a Johannesson, Petra4 aut |
| 700 | 1 | a Johansson, Magnus J4 aut |
| 700 | 1 | a Kemmitt, Paul D4 aut |
| 700 | 1 | a Lindmark, Bo T4 aut |
| 700 | 1 | a Morentin Gutierrez, Pablo4 aut |
| 700 | 1 | a Noeske, Tobias A4 aut |
| 700 | 1 | a Nordin, Andreas4 aut |
| 700 | 1 | a O'Donnell, Charles J4 aut |
| 700 | 1 | a Petersson, Annika U4 aut |
| 700 | 1 | a Redzic, Alma4 aut |
| 700 | 1 | a Turnbull, Andrew V4 aut |
| 700 | 1 | a Vinblad, Johanna4 aut |
| 710 | 2 | a Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden4 org |
| 773 | 0 | t Journal of Medicinal Chemistryd : American Chemical Society (ACS)g 55:23, s. 10610-10629q 55:23<10610-10629x 0022-2623x 1520-4804 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211228 |
| 856 | 4 8 | u https://doi.org/10.1021/jm301296t |
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