Search: WFRF:(Mortensen Klaus L.)
> (2021) >
Efficacy of the TMP...
Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial
-
- Gunst, Jesper D. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Staerke, Nina B. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Pahus, Marie H. (author)
- Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
-
show more...
-
- Kristensen, Lena H. (author)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
-
- Bodilsen, Jacob (author)
- Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark
-
- Lohse, Nicolai (author)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark; Deptarment of Clinical Medicine, Copenhagen University, Copenhagen, Denmark
-
- Dalgaard, Lars S. (author)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
-
- Brønnum, Dorthe (author)
- Centre for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark
-
- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Cardiology
-
- Hønge, Bo (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark
-
- Johansen, Isik S. (author)
- Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Denmark
-
- Monrad, Ida (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Erikstrup, Christian (author)
- Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark; Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
-
- Rosendal, Regitze (author)
- Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
-
- Vilstrup, Emil (author)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
-
- Mariager, Theis (author)
- Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark
-
- Bove, Dorthe G. (author)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark
-
- Offersen, Rasmus (author)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
-
- Shakar, Shakil (author)
- Deptarment of Internal Medicine, North Denmark Regional Hospital, Denmark; Deptarment of Emergency Medicine, North Denmark Regional Hospital, Denmark
-
- Cajander, Sara, 1980- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Deptarment of Infectious Diseases
-
- Jørgensen, Nis P. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark
-
- Sritharan, Sajitha S. (author)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
-
- Breining, Peter (author)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
-
- Jespersen, Søren (author)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark
-
- Mortensen, Klaus L. (author)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
-
- Jensen, Mads L. (author)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
-
- Kolte, Lilian (author)
- Deptarment of Lung and Infectious Diseases, Copenhagen University Hospital, Hillerød, Denmark
-
- Frattari, Giacomo S. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Larsen, Carsten S. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Storgaard, Merete (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Nielsen, Lars P. (author)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark
-
- Tolstrup, Martin (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
-
- Sædder, Eva A. (author)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark
-
- Østergaard, Lars J. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
-
- Ngo, Hien T. T. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Jensen, Morten H. (author)
- Deptarment of Health Science and Technology, Aalborg University, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark
-
- Højen, Jesper F. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
-
- Kjolby, Mads (author)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; DANDRITE, Deptarment of Biomedicine, Aarhus University, Aarhus Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark; University of Dundee, Scotland, United Kingdom
-
- Søgaard, Ole S. (author)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
-
show less...
-
(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
-
In: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 35
- Related links:
-
https://doi.org/10.1...
-
show more...
-
http://www.thelancet...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as ≥2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.Findings: 137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group (P = 0·31). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0·82 (95% confidence interval [CI], 0·24 to 2·79; P = 0·75). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0·22 log10 copies/mL (p <0·05) and -0·82 log10 in the placebo group (P <0·05).Interpretation: Under this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gunst, Jesper D.
-
Staerke, Nina B.
-
Pahus, Marie H.
-
Kristensen, Lena ...
-
Bodilsen, Jacob
-
Lohse, Nicolai
-
show more...
-
Dalgaard, Lars S ...
-
Brønnum, Dorthe
-
Fröbert, Ole, 19 ...
-
Hønge, Bo
-
Johansen, Isik S ...
-
Monrad, Ida
-
Erikstrup, Chris ...
-
Rosendal, Regitz ...
-
Vilstrup, Emil
-
Mariager, Theis
-
Bove, Dorthe G.
-
Offersen, Rasmus
-
Shakar, Shakil
-
Cajander, Sara, ...
-
Jørgensen, Nis P ...
-
Sritharan, Sajit ...
-
Breining, Peter
-
Jespersen, Søren
-
Mortensen, Klaus ...
-
Jensen, Mads L.
-
Kolte, Lilian
-
Frattari, Giacom ...
-
Larsen, Carsten ...
-
Storgaard, Meret ...
-
Nielsen, Lars P.
-
Tolstrup, Martin
-
Sædder, Eva A.
-
Østergaard, Lars ...
-
Ngo, Hien T. T.
-
Jensen, Morten H ...
-
Højen, Jesper F.
-
Kjolby, Mads
-
Søgaard, Ole S.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
eClinicalMedicin ...
- By the university
-
Örebro University