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3D genomics across ...
3D genomics across the tree of life reveals condensin II as a determinant of architecture type
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- Hoencamp, Claire (author)
- Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- Dudchenko, Olga (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.
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- Elbatsh, Ahmed M. O. (author)
- Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.;Novartis Inst Biomed Res, CH-4002 Basel, Switzerland.
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show more...
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- Brahmachari, Sumitabha (author)
- Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.
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- Raaijmakers, Jonne A. (author)
- Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.
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- van Schaik, Tom (author)
- Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- Cacciatore, Angela Sedeno (author)
- Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- Contessoto, Vinicius G. (author)
- Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Sao Paulo State Univ UNESP, Inst Biosci Letters & Exact Sci, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil.
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- van Heesbeen, Roy G. H. P. (author)
- Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.;Janssen Vaccines & Prevent BV, NL-2333 CN Leiden, Netherlands.
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- van den Broek, Bram (author)
- Netherlands Canc Inst, BioImaging Facil, NL-1066 CX Amsterdam, Netherlands.
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- Mhaskar, Aditya N. (author)
- Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.;Univ Med Ctr Rotterdam, Erasmus MC, Dept Dev Biol, NL-3015 GD Rotterdam, Netherlands.
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- Teunissen, Hans (author)
- Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- St Hilaire, Brian Glenn (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
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- Weisz, David (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
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- Omer, Arina D. (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Pham, Melanie (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Colaric, Zane (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Yang, Zhenzhen (author)
- ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China.
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- Rao, Suhas S. P. (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.
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- Mitra, Namita (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
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- Lui, Christopher (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Yao, Weijie (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Khan, Ruqayya (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
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- Moroz, Leonid L. (author)
- Univ Florida, Whitney Lab, Gainesville, FL 32611 USA.;Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA.
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- Kohn, Andrea (author)
- Univ Florida, Whitney Lab, Gainesville, FL 32611 USA.;Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA.
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- St Leger, Judy (author)
- Cornell Univ, Dept Biosci, Coll Vet Med, Ithaca, NY 14853 USA.
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- Mena, Alexandria (author)
- SeaWorld San Diego, San Diego, CA 92109 USA.
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- Holcroft, Karen (author)
- Moody Gardens, Galveston, TX 77554 USA.
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- Gambetta, Maria Cristina (author)
- Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
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- Lim, Fabian (author)
- Univ Calif San Diego, Dept Med & Mol Biol, La Jolla, CA 92093 USA.
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- Farley, Emma (author)
- Univ Calif San Diego, Dept Med & Mol Biol, La Jolla, CA 92093 USA.
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- Stein, Nils (author)
- Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, D-06466 Seeland, Germany.;Georg August Univ Gottingen, Ctr Integrated Breeding Res CiBreed, Dept Crop Sci, D-37075 Gottingen, Germany.;Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.
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- Haddad, Alexander (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.
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- Chauss, Daniel (author)
- NIDDK, NIH, Bethesda, MD 20892 USA.
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- Mutlu, Ayse Sena (author)
- Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
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- Wang, Meng C. (author)
- Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA.;Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA.
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- Young, Neil D. (author)
- Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia.
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- Hildebrandt, Evin (author)
- ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI 48823 USA.;Zoetis, VMRD Global Biol Res, Kalamazoo, MI 49007 USA.
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- Cheng, Hans H. (author)
- ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI 48823 USA.
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- Knight, Christopher J. (author)
- Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USA.
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- Burnham, Theresa L. U. (author)
- Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA.;San Diego State Univ, Coastal & Marine Inst, San Diego, CA 92106 USA.;San Diego State Univ, Dept Biol, San Diego, CA 92106 USA.
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- Hovel, Kevin A. (author)
- San Diego State Univ, Coastal & Marine Inst, San Diego, CA 92106 USA.;San Diego State Univ, Dept Biol, San Diego, CA 92106 USA.
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- Beel, Andrew J. (author)
- Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.
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- Mattei, Pierre-Jean (author)
- Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.
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- Kornberg, Roger D. (author)
- Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.
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- Warren, Wesley C. (author)
- Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA.
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- Cary, Gregory (author)
- Jackson Lab, Bar Harbor, ME 04609 USA.
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- Gomez-Skarmeta, Jose Luis (author)
- Univ Pablo de Olavide, Ctr Andaluz Biol Desarrollo, CSIC, Seville 41013, Spain.
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- Hinman, Veronica (author)
- Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA.
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
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- Di Palma, Federica (author)
- Univ East Anglia, Dept Biol Sci, Norwich NR4 7TJ, Norfolk, England.
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- Maeshima, Kazuhiro (author)
- Natl Inst Genet, Genome Dynam Lab, Mishima, Shizuoka 4118540, Japan.;Sokendai Grad Univ Adv Studies, Dept Genet, Mishima, Shizuoka 4118540, Japan.
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- Multani, Asha S. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.
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Pathak, Sen (author)
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- Nel-Themaat, Liesl (author)
- Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.;Univ Colorado Adv Reprod Med, Denver, CO 80238 USA.
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- Behringer, Richard R. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.
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- Kaur, Parwinder (author)
- Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.
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- Medema, Rene H. (author)
- Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.
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- van Steensel, Bas (author)
- Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- de Wit, Elzo (author)
- Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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- Onuchic, Jose N. (author)
- Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA.;Rice Univ, Dept Chem, Houston, TX 77005 USA.;Rice Univ, Dept Biosci, Houston, TX 77005 USA.
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- Di Pierro, Michele (author)
- Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Northeastern Univ, Dept Phys, Boston, MA 02115 USA.
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- Aiden, Erez Lieberman (author)
- Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China.;Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
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- Rowland, Benjamin D. (author)
- Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.
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Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2021
- 2021
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 372:6545, s. 984-989
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Hoencamp, Claire
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Dudchenko, Olga
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Elbatsh, Ahmed M ...
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Brahmachari, Sum ...
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Raaijmakers, Jon ...
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van Schaik, Tom
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show more...
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Cacciatore, Ange ...
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Contessoto, Vini ...
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van Heesbeen, Ro ...
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van den Broek, B ...
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Mhaskar, Aditya ...
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Teunissen, Hans
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St Hilaire, Bria ...
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Weisz, David
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Omer, Arina D.
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Pham, Melanie
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Colaric, Zane
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Yang, Zhenzhen
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Rao, Suhas S. P.
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Mitra, Namita
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Lui, Christopher
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Yao, Weijie
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Khan, Ruqayya
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Moroz, Leonid L.
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Kohn, Andrea
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St Leger, Judy
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Mena, Alexandria
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Holcroft, Karen
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Gambetta, Maria ...
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Lim, Fabian
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Farley, Emma
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Stein, Nils
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Haddad, Alexande ...
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Chauss, Daniel
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Mutlu, Ayse Sena
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Wang, Meng C.
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Young, Neil D.
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Hildebrandt, Evi ...
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Cheng, Hans H.
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Knight, Christop ...
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Burnham, Theresa ...
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Hovel, Kevin A.
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Beel, Andrew J.
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Mattei, Pierre-J ...
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Kornberg, Roger ...
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Warren, Wesley C ...
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Cary, Gregory
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Gomez-Skarmeta, ...
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Hinman, Veronica
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Lindblad-Toh, Ke ...
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Di Palma, Federi ...
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Maeshima, Kazuhi ...
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Multani, Asha S.
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Pathak, Sen
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Nel-Themaat, Lie ...
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Behringer, Richa ...
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Kaur, Parwinder
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Medema, Rene H.
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van Steensel, Ba ...
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de Wit, Elzo
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Onuchic, Jose N.
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Di Pierro, Miche ...
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Aiden, Erez Lieb ...
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Rowland, Benjami ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Genetics
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Science
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Uppsala University