WFRF:(Mustjoki S)
Search: WFRF:(Mustjoki S) > (2001-2004) > Isolated lymphatic ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.
-
- Mäkinen, Taija (author)
- Uppsala universitet,Vaskulärbiologi
- Veikkola, T (author)
- Mustjoki, S (author)
- show more...
- Karpanen, T (author)
- Catimel, B (author)
- Nice, E C (author)
- Wise, L (author)
- Mercer, A (author)
- Kowalski, H (author)
- Kerjaschki, D (author)
- Stacker, S A (author)
- Achen, M G (author)
- Alitalo, K (author)
- show less...
- (creator_code:org_t)
- Wiley, 2001
- 2001
- English.
- In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 20:17
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Vascular endothelial growth factor receptor-3 (VEGFR-3/Flt4) binds two known members of the VEGF ligand family, VEGF-C and VEGF-D, and has a critical function in the remodelling of the primary capillary vasculature of midgestation embryos. Later during development, VEGFR-3 regulates the growth and maintenance of the lymphatic vessels. In the present study, we have isolated and cultured stable lineages of blood vascular and lymphatic endothelial cells from human primary microvascular endothelium by using antibodies against the extracellular domain of VEGFR-3. We show that VEGFR-3 stimulation alone protects the lymphatic endothelial cells from serum deprivation-induced apoptosis and induces their growth and migration. At least some of these signals are transduced via a protein kinase C-dependent activation of the p42/p44 MAPK signalling cascade and via a wortmannin-sensitive induction of Akt phosphorylation. These results define the critical role of VEGF-C/VEGFR-3 signalling in the growth and survival of lymphatic endothelial cells. The culture of isolated lymphatic endothelial cells should now allow further studies of the molecular properties of these cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Mäkinen, Taija
- Veikkola, T
- Mustjoki, S
- Karpanen, T
- Catimel, B
- Nice, E C
- show more...
- Wise, L
- Mercer, A
- Kowalski, H
- Kerjaschki, D
- Stacker, S A
- Achen, M G
- Alitalo, K
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- Articles in the publication
- EMBO Journal
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
