WFRF:(Newman H.)
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Serum cystatin C measured by automated immunoassay : a more sensitive marker of changes in GFR than serum creatinine
- Newman, D J (author)
- Thakkar, H (author)
- Edwards, R G (author)
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- Wilkie, M (author)
- White, T (author)
- Price, C P (author)
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- (creator_code:org_t)
- Elsevier BV, 1995
- 1995
- English.
- In: Kidney International. - : Elsevier BV. - 0085-2538. ; 47, s. 312-318
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Serum cystatin C has been suggested as a new marker of GFR. For the introduction of this marker into clinical use a rapid and automated method is required. We have developed and validated an assay for serum cystatin C using latex particle-enhanced immunoturbidimetry. Intra- and inter-assay precision were < 3% and < 5% across the assay range. Analytical recovery was 93 +/- 3.8% and no lack of parallelism was demonstrated. Regression analysis of a method comparison with an enzyme-enhanced radial-immunodiffusion method, gave PETIA = 0.074 + 0.93 x SRID, r = 0.98, N = 100. Inter-assay precision profiles showed cystatin C was measured with two-fold better precision than creatinine on the same analyzer. Cystatin C measurement was neither interfered with by icterus nor by hemolysis. 1/cystatin C versus 1/creatinine concentrations gave r = 0.67, N = 469. Comparison of Cr EDTA GFR with 1/cystatin C and 1/creatinine gave r = 0.81 and 0.50, respectively, N = 206. Calculating diagnostic sensitivity for abnormal GFR showed cystatin C to be significantly (P < 0.05) more sensitive than creatinine (71.4 vs. 52.4%). Cystatin C measurement using PETIA technology can be automated on the same instruments used routinely for the measurement of creatinine and offers better analytical performance and probably improved clinical sensitivity as a screening test for early renal damage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Biomarkers
- Creatinine/blood
- Cystatin C
- Cystatins/blood
- Cysteine Proteinase Inhibitors/blood
- Glomerular Filtration Rate
- Humans
- Immunoassay/methods
- Kidney Diseases/blood
- Latex
- Microspheres
- Nephelometry and Turbidimetry/methods
- Reproducibility of Results
- Sensitivity and Specificity
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- art (subject category)
- ref (subject category)
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- Newman, D J
- Thakkar, H
- Edwards, R G
- Wilkie, M
- White, T
- Grubb, Anders O.
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