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Conditioning-based outcomes after allogeneic transplantation for myeloma following a prior autologous transplant (1991-2012) on behalf of EBMT CMWP
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- Hayden, Patrick J. (author)
- St James Hosp, Ireland
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- Iacobelli, Simona (author)
- Tor Vergata Univ Rome, Italy
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- Antonio Perez-Simon, Jose (author)
- Hosp Univ Virgen Rocio, Spain; Univ Seville, Spain
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- van Biezen, Anja (author)
- Leiden EBMT Data Off, Netherlands
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- Minnema, Monique (author)
- Univ Med Ctr Utrecht, Netherlands
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- Niittyvuopio, Riitta (author)
- HUCH Comprehens Canc Ctr, Finland
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- Schoenland, Stefan (author)
- Heidelberg Univ, Germany
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- Meijer, Ellen (author)
- Vrije Univ Amsterdam Med Ctr, Netherlands
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- Blaise, Didier (author)
- Marseille Inst Paoli Calmettes, France
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- Milpied, Noel (author)
- CHU Bordeaux, France
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- Marquez-Malaver, Francisco J. (author)
- Hosp Univ Virgen Rocio, Spain; Univ Seville, Spain
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- Veelken, Joan Hendrik (author)
- Leiden Univ, Netherlands
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- Maertens, Johan (author)
- Univ Hosp Gasthuisberg, Belgium
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- Michallet, Mauricette (author)
- Ctr Hosp Lyon Sud, France
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- Cammenga, Jörg (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- NGuyen, Stephanie (author)
- Hop La Pitie Salpetriere, France
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- Niederwieser, Dietger (author)
- Univ Hosp Leipzig, Germany
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- Hunault-Berger, Mathilde (author)
- CHRU Angers, France
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- Bourhis, Jean Henri (author)
- Gustave Roussy Inst Cancerol, France
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- Passweg, Jakob (author)
- Univ Hosp Basel, Switzerland
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- Bermudez, Arancha (author)
- FEA Serv Hematol, Spain
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- Chalandon, Yves (author)
- Hop Univ Geneve, Switzerland; Univ Geneva, Switzerland
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- Yakoub-Agha, Ibrahim (author)
- Hop Claude Huriez, France
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- Garderet, Laurent (author)
- Hosp St Antoine, France
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- Kroeger, Nicolaus (author)
- Univ Hosp Eppendorf, Germany
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(creator_code:org_t)
- 2020
- English.
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In: European Journal of Haematology. - : WILEY. - 0902-4441 .- 1600-0609.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives The aim of this study was to compare the effect of the intensity of conditioning approaches used in allogeneic transplantation in myeloma-reduced intensity conditioning (RIC), non-myeloablative (NMA), myeloablative conditioning (MAC) or Auto-AlloHCT-on outcomes in patients who had had a prior autologous transplant. Methods A retrospective analysis of the EBMT database (1991-2012) was performed. Results A total of 344 patients aged between 40 and 60 years at the time of alloHCT were identified: 169 RIC, 69 NMA, 65 MAC and 41 Auto-Allo transplants. At a median follow-up of 54 months, the probabilities of overall survival (OS) at 5 years were 39% (95% CI 31%-47%), 45% (95% CI 32%-57%), 19% (95% CI 6%-32%) and 34% (95% CI 17%-51%), respectively. Status at allogeneic HCT other than CR or PR conferred a 70% higher risk of death and a 40% higher risk of relapse. OS was markedly lower in the MAC group (P = .004). MAC alloHCT was associated with a higher risk of death than RIC alloHCT until 2002 (HR = 4.1, P amp;lt; .001) but not after 2002 (HR = 1.2, P = .276). Conclusion From 1991 to 2002, MAC was associated with poorer OS. Between 2003 and 2012, there were no significant differences in outcomes based on these different approaches.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- allogeneic transplantation; CMWP; conditioning; EBMT; myeloma
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hayden, Patrick ...
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Iacobelli, Simon ...
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Antonio Perez-Si ...
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van Biezen, Anja
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Minnema, Monique
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Niittyvuopio, Ri ...
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show more...
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Schoenland, Stef ...
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Meijer, Ellen
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Blaise, Didier
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Milpied, Noel
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Marquez-Malaver, ...
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Veelken, Joan He ...
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Maertens, Johan
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Michallet, Mauri ...
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Cammenga, Jörg
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NGuyen, Stephani ...
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Niederwieser, Di ...
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Hunault-Berger, ...
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Bourhis, Jean He ...
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Passweg, Jakob
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Bermudez, Aranch ...
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Chalandon, Yves
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Yakoub-Agha, Ibr ...
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Garderet, Lauren ...
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Kroeger, Nicolau ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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European Journal ...
- By the university
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Linköping University