Sökning: WFRF:(Nieminen Anni I) > (2024) > The gut commensal B...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05301naa a2200469 4500 | |
001 | oai:DiVA.org:umu-224120 | |
003 | SwePub | |
008 | 240514s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2241202 URI |
024 | 7 | a https://doi.org/10.1038/s41467-024-47594-w2 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Holmberg, Sandrau Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)saho0042 |
245 | 1 0 | a The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids |
264 | 1 | b Nature Publishing Group,c 2024 |
338 | a electronic2 rdacarrier | |
520 | a Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal Blautia, and supplementation of Blautia coccoides to mice confirmed its mucus-stimulating capacity. Mechanistically, B. coccoides stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
700 | 1 | a Feeney, Rachel H.u Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)rafe0005 |
700 | 1 | a Prasoodanan P.K, Vishnuu Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)vipr0013 |
700 | 1 | a Puértolas Balint, Fabiolau Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)fapu0002 |
700 | 1 | a Singh, Dhirendra K.u Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)dhku0005 |
700 | 1 | a Wongkuna, Supapitu Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)suwo0004 |
700 | 1 | a Zandbergen, Lotteu Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut |
700 | 1 | a Hauner, Hansu Institute in Nutritional Medicine, TU Munich, Munich, Germany; TU Munich, School of Medicine, Munich, Germany4 aut |
700 | 1 | a Brandl, Beateu ZIEL Institute for Food and Health, TU Munich, Munich, Germany4 aut |
700 | 1 | a Nieminen, Anni I.u Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Skurk, Thomasu ZIEL Institute for Food and Health, TU Munich, Munich, Germany4 aut |
700 | 1 | a Schröder, Björnu Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)bjsc0005 |
710 | 2 | a Umeå universitetb Molekylär Infektionsmedicin, Sverige (MIMS)4 org |
773 | 0 | t Nature Communicationsd : Nature Publishing Groupg 15:1q 15:1x 2041-1723 |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1857809/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224120 |
856 | 4 8 | u https://doi.org/10.1038/s41467-024-47594-w |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy