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Risk prediction of ...
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Börschel, Christin S.Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
(författare)
Risk prediction of atrial fibrillation and its complications in the community using hs troponin I
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2023-01-17
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John Wiley & Sons,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-204076
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-204076URI
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https://doi.org/10.1111/eci.13950DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Aims: Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.Methods: We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) across European community cohorts in comparison to CVRF and established biomarkers (C-reactive protein, N-terminal pro B-type natriuretic peptide).Results: During a median follow-up of 7.7 years, 1734 (3.8%) participants developed AF. Those in the highest hsTnI quarter (≥4.2 ng/L) had a 3.91-fold (95% confidence interval (CI) 3.30, 4.63; p <.01) risk for developing AF compared to the lowest quarter (<1.4 ng/L). In multivariable-adjusted Cox proportional hazards models a statistically significant association was seen between hsTnI and AF (hazard ratio (HR) per 1 standard deviation (SD) increase in log10(hsTnI) 1.08; 95% CI 1.01, 1.16; p =.03). Inclusion of hsTnI did improve model discrimination (C-index CVRF 0.811 vs. C-index CVRF and hsTnI 0.813; p <.01). Higher hsTnI concentrations were associated with heart failure (HR per SD 1.37; 95% CI 1.12, 1.68; p <.01) and overall mortality (HR per SD 1.24; 95% CI 1.09, 1.41; p <.01).Conclusion: hsTnI as a biomarker of myocardial injury does not improve prediction of AF incidence beyond classical CVRF and NT-proBNP. However, it is associated with the AF-related disease heart failure and mortality likely reflecting underlying subclinical cardiovascular impairment.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Geelhoed, BastiaanDepartment of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
(författare)
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Niiranen, TeemuFinnish Institute for Health and Welfare, Helsinki, Finland; Deparment of Internal Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland
(författare)
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Camen, StephanDepartment of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
(författare)
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Donati, Maria BenedettaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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Havulinna, Aki S.Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
(författare)
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Gianfagna, FrancescoResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy
(författare)
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Palosaari, TarjaFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Jousilahti, PekkaFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Kontto, JukkaFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Vartiainen, ErkkiFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Ojeda, Francisco M.Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany
(författare)
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den Ruijter, Hester M.Laboratory for Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
(författare)
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Costanzo, SimonaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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de Gaetano, GiovanniDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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Di Castelnuovo, AugustoMediterranea Cardiocentro, Naples, Italy
(författare)
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Linneberg, AllanDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
(författare)
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Vishram-Nielsen, Julie K.Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
(författare)
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Løchen, Maja-LisaDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
(författare)
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Koenig, WolfgangGerman Heart Centre Munich, Technical University of Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
(författare)
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Jørgensen, TorbenCentre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Kuulasmaa, KariFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Blankenberg, StefanDepartment of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
(författare)
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Iacoviello, LiciaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Zeller, TanjaDepartment of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Söderberg, StefanUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)stso0001
(författare)
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Salomaa, VeikkoFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Schnabel, Renate B.Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
(författare)
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Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, GermanyFinnish Institute for Health and Welfare, Helsinki, Finland; Deparment of Internal Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Clinical Investigation: John Wiley & Sons53:50014-29721365-2362
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- Av författaren/redakt...
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Börschel, Christ ...
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Geelhoed, Bastia ...
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Niiranen, Teemu
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Camen, Stephan
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Donati, Maria Be ...
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Havulinna, Aki S ...
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visa fler...
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Gianfagna, Franc ...
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Palosaari, Tarja
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Jousilahti, Pekk ...
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Kontto, Jukka
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Vartiainen, Erkk ...
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Ojeda, Francisco ...
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den Ruijter, Hes ...
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Costanzo, Simona
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de Gaetano, Giov ...
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Di Castelnuovo, ...
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Linneberg, Allan
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Vishram-Nielsen, ...
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Løchen, Maja-Lis ...
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Koenig, Wolfgang
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Jørgensen, Torbe ...
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Kuulasmaa, Kari
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Blankenberg, Ste ...
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Iacoviello, Lici ...
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Zeller, Tanja
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Söderberg, Stefa ...
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Salomaa, Veikko
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Schnabel, Renate ...
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