Cd-Metallothioneins in Three Additional Tetrahymena Species: Intragenic Repeat Patterns and Induction by Metal Ions

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Fältnamn	Indikatorer	Metadata
000		03096naa a2200445 4500
001		oai:DiVA.org:uu-230509
003		SwePub
008		140826s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2305092 URI
024	7	a https://doi.org/10.1111/jeu.121122 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Chang, Yue4 aut
245	1 0	a Cd-Metallothioneins in Three Additional Tetrahymena Species :b Intragenic Repeat Patterns and Induction by Metal Ions
264		c 2014-05-16
264	1	b Wiley,c 2014
338		a print2 rdacarrier
520		a Ciliate metallothioneins (MTs) possess many unique features compared to the "classic" MTs in other organisms, but they have only been studied in a small number of species. In this study, we investigated cDNAs encoding subfamily 7a metallothioneins (CdMTs) in three Tetrahymena species (T. hegewischi, T. malaccensis, and T. mobilis). Four CdMT genes (ThegMT1, ThegMT2, TmalMT1, and TmobMT1) were cloned and characterized. They share high sequence similarity to previously identified subfamily 7a MT members. Tetrahymena CdMTs exhibit a remarkably regular intragenic repeat homology. The CdMT sequences were divided into two main types of modules, which had been previously described, and which we name "A" and "B". ThegMT2 was identified as the first MT isoform solely composed of module "B". A phylogenetic analysis of individual modules of every characterized Tetrahymena CdMT rigorously documents the conclusion that modules are important units of CdMT evolution, which have undergone frequent and rapid gain/loss and shuffling. The transcriptional activity of the four newly identified genes was measured under different heavy metal exposure (Cd, Cu, Zn, Pb) using real-time quantitative PCR. The results showed that these genes were differentially induced after short (1 h) or long (24 h) metal exposure. The evolutionary diversity of Tetrahymena CdMTs is further discussed with regard to their induction by metal ions.
650	7	a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653		a ciliate
653		a heavy metal stress
653		a metallothionein evolution
653		a modular repeat
653		a real-time quantitative PCR
700	1	a Liu, Guanglong4 aut
700	1	a Guo, Lina4 aut
700	1	a Liu, Hongbo4 aut
700	1	a Yuan, Dongxia4 aut
700	1	a Xiong, Jie4 aut
700	1	a Ning, Yingzhi4 aut
700	1	a Fu, Chengjieu Uppsala universitet,Systematisk biologi4 aut0 (Swepub:uu)chefu803
700	1	a Miao, Wei4 aut
710	2	a Uppsala universitetb Systematisk biologi4 org
773	0	t Journal of Eukaryotic Microbiologyd : Wileyg 61:4, s. 333-342q 61:4<333-342x 1066-5234x 1550-7408
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230509
856	4 8	u https://doi.org/10.1111/jeu.12112

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Av författaren/redakt...: Chang, Yue; Liu, Guanglong; Guo, Lina; Liu, Hongbo; Yuan, Dongxia; Xiong, Jie; visa fler...; Ning, Yingzhi; Fu, Chengjie; Miao, Wei; visa färre...

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Av lärosätet: Uppsala universitet

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