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Crotofolane Diterpe...
Crotofolane Diterpenoids and Other Constituents Isolated from Croton kilwae.
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- Mahambo, Emanuel T (author)
- Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, Dar Es Salaam 35061, Tanzania.
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- Uwamariya, Colores (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis Virol, S-41346 Gothenburg, Sweden.
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- Miah, Masum (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis Virol, S-41346 Gothenburg, Sweden.,Univ Campinas UNICAMP, Inst Biol IB, Dept Genet Evolut Microbiol & Immunol, Lab Trop Dis Prof Dr Luiz Jacinto da Silva, BR-13083970 Campinas, Brazil.
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- Clementino, Leandro da Costa (author)
- Univ Campinas UNICAMP, Inst Biol IB, Dept Genet Evolut Microbiol & Immunol, Lab Trop Dis Prof Dr Luiz Jacinto da Silva, BR-13083970 Campinas, Brazil.
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- Alvarez, Luis Carlos Salazar (author)
- Univ Campinas UNICAMP, Inst Biol IB, Dept Genet Evolut Microbiol & Immunol, Lab Trop Dis Prof Dr Luiz Jacinto da Silva, BR-13083970 Campinas, Brazil.
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- Di Santo Metzler, Gabriela Paula, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,CARe - Centrum för antibiotikaresistensforskning,Department of Chemistry and Molecular Biology,Centre for antibiotic resistance research, CARe,Univ Gothenburg, Dept Chem & Mol Biol, SE-40530 Gothenburg, Sweden.;Univ Gothenburg, Ctr Antibiot Resistance Res CARe, SE-40530 Gothenburg, Sweden.
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- Trybala, Edward, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis Virol, S-41346 Gothenburg, Sweden.
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- Said, Joanna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis Virol, S-41346 Gothenburg, Sweden.
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- Wieske, Hermina, 1994- (author)
- Uppsala universitet,Organisk kemi
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- Ward, Jas S (author)
- Univ Jyvaskyla, Dept Chem, Jyvaskyla 40014, Finland.
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- Rissanen, Kari (author)
- Univ Jyvaskyla, Dept Chem, Jyvaskyla 40014, Finland.
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- Munissi, Joan J E (author)
- Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, Dar Es Salaam 35061, Tanzania.
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Costa, Fabio T M (author)
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- Sunnerhagen, Per, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,CARe - Centrum för antibiotikaresistensforskning,Department of Chemistry and Molecular Biology,Centre for antibiotic resistance research, CARe,Univ Gothenburg, Dept Chem & Mol Biol, SE-40530 Gothenburg, Sweden.;Univ Gothenburg, Ctr Antibiot Resistance Res CARe, SE-40530 Gothenburg, Sweden.
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis Virol, S-41346 Gothenburg, Sweden.
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- Nyandoro, Stephen S (author)
- Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, Dar Es Salaam 35061, Tanzania.
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- Erdélyi, Máté, 1975- (author)
- Uppsala universitet,Organisk kemi
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Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, Dar Es Salaam 35061, Tanzania Institutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)
- 2023-02-07
- 2023
- English.
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In: Journal of Natural Products. - : American Chemical Society (ACS). - 1520-6025 .- 0163-3864. ; 86:2, s. 380-389
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Six new crotofolane diterpenoids (1-6) and 13 known compounds (7-19) were isolated from the MeOH-CH2Cl2 (1:1, v/v) extracts of the leaves and stem bark of Croton kilwae. The structures of the new compounds were elucidated by extensive analysis of spectroscopic and mass spectrometric data. The structure of crotokilwaepoxide A (1) was confirmed by single-crystal X-ray diffraction, allowing for the determination of its absolute configuration. The crude extracts and the isolated compounds were investigated for antiviral activity against respiratory syncytial virus (RSV) and human rhinovirus type-2 (HRV-2) in HEp-2 and HeLa cells, respectively, for antibacterial activity against the Gram-positive Bacillus subtilis and the Gram-negative Escherichia coli, and for antimalarial activity against the Plasmodium falciparum Dd2 strain. ent-3β,19-Dihydroxykaur-16-ene (7) and ayanin (16) displayed anti-RSV activities with IC50 values of 10.2 and 6.1 μM, respectively, while exhibiting only modest cytotoxic effects on HEp-2 cells that resulted in selectivity indices of 4.9 and 16.4. Compounds 2 and 5 exhibited modest anti-HRV-2 activity (IC50 of 44.6 μM for both compounds), while compound 16 inhibited HRV-2 with an IC50 value of 1.8 μM. Compounds 1-3 showed promising antiplasmodial activities (80-100% inhibition) at a 50 μM concentration.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Humans
- Croton
- chemistry
- HeLa Cells
- Antimalarials
- pharmacology
- Diterpenes
- chemistry
- Crystallography
- X-Ray
- Plant Extracts
- chemistry
- Molecular Structure
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mahambo, Emanuel ...
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Uwamariya, Color ...
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Miah, Masum
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Clementino, Lean ...
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Alvarez, Luis Ca ...
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Di Santo Metzler ...
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Trybala, Edward, ...
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Said, Joanna
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Wieske, Hermina, ...
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Ward, Jas S
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Rissanen, Kari
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Munissi, Joan J ...
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Costa, Fabio T M
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Sunnerhagen, Per ...
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Bergström, Tomas ...
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Nyandoro, Stephe ...
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Erdélyi, Máté, 1 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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Journal of Natur ...
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University of Gothenburg
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Uppsala University