Sökning: WFRF:(O'Byrne P.) > (2005-2009) > Budesonide/Formoter...
Fältnamn | Indikatorer | Metadata |
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000 | 02916naa a2200325 4500 | |
001 | oai:gup.ub.gu.se/60049 | |
003 | SwePub | |
008 | 240528s2005 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/600492 URI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a O'Byrne P, M.4 aut |
245 | 1 0 | a Budesonide/Formoterol combination therapy as both maintenance and reliever medication in asthma |
264 | 1 | c 2005 |
520 | a Asthma control is improved by combining inhaled corticosteroids with long-acting beta(2)-agonists. However, fluctuating asthma control still occurs. We hypothesized that in patients receiving low maintenance dose budesonide/formoterol (bud/form), replacing short-acting beta(2)-agonist (SABA) reliever with as-needed bud/form would provide rapid symptom relief and simultaneous adjustment in antiinflammatory therapy, thereby reducing exacerbations. In this double-blind, randomized, parallel-group study, 2,760 patients with asthma aged 4-80 years (FEV(1) 60-100% predicted) received either terbutaline 0.4 mg as SABA with bud/form 80/4.5 mug twice a day (bud/form + SABA) or bud 320 mug twice a day (bud + SABA) or bud/form 80/4.5 mug twice a day with 80/4.5 mug as-needed (bud/form maintenance + relief). Children used a once-nocte maintenance dose. Bud/form maintenance + relief prolonged time to first severe exacerbation (p < 0.001; primary endpoint), resulting in a 45-47% lower exacerbation risk versus bud/form + SABA (hazard ratio, 0.55; 95% confidence interval, 0.44, 0.67) or bud + SABA (hazard ratio, 0.53; 95% confidence interval 0.43, 0.65). Bud/form maintenance + relief also prolonged the time to the first, second, and third exacerbation requiring medical intervention (p < 0.001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
700 | 1 | a Bisgaard, H.4 aut |
700 | 1 | a Godard, P. P.4 aut |
700 | 1 | a Pistolesi, M.4 aut |
700 | 1 | a Palmqvist, Mona,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology4 aut0 (Swepub:gu)xpamon |
700 | 1 | a Zhu, Y.4 aut |
700 | 1 | a Ekström, T.4 aut |
700 | 1 | a Bateman, E. D.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi4 org |
773 | 0 | t Am J Respir Crit Care Medg 171:2, s. 129-36q 171:2<129-36 |
856 | 4 8 | u https://gup.ub.gu.se/publication/60049 |
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