Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues

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Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues

Wall, Rebecca, 1979- (author): Alimentary Pharmabiotic Centre, Cork, Ireland; Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland; Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland,Nutrition-Gut-Brain Interactions Research Centre

Ross, R. Paul (author): Alimentary Pharmabiotic Centre, Cork, Ireland; Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

Shanahan, Fergus (author): Alimentary Pharmabiotic Centre, Cork, Ireland

O'Mahony, Liam (author): Alimentary Pharmabiotic Centre, Cork, Ireland

O'Mahony, Caitlin (author): Alimentary Pharmabiotic Centre, Cork, Ireland

Coakley, Mairead (author): Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

Hart, Orla (author): Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

Lawlor, Peadar (author): Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

Quigley, Eamonn M. (author): Alimentary Pharmabiotic Centre, Cork, Ireland

Kiely, Barry (author): Alimentary Pharmabiotic Centre, Cork, Ireland

Fitzgerald, Gerald F. (author): Alimentary Pharmabiotic Centre, Cork, Ireland; Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland

Stanton, Catherine (author): Alimentary Pharmabiotic Centre, Cork, Ireland; Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

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Bethesda, USA : American Society for Nutrition, 2009
2009
English.
In: American Journal of Clinical Nutrition. - Bethesda, USA : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 89:5, s. 1393-1401

Related links:: https://academic.oup...; show more...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Recent reports suggest that the metabolic activity of the gut microbiota may contribute to the pathogenesis of obesity and hepatic steatosis.Objective: The objective was to determine whether the fat composition of host tissues might be influenced by oral administration of commensal bifidobacteria previously shown by us to produce bioactive isomers of conjugated linoleic acid (CLA).Design: Murine trials were conducted in which linoleic acid-supplemented diets were fed with or without Bifidobacterium breve NCIMB 702258 (daily dose of 10(9) microorganisms) to healthy BALB/c mice and to severe combined immunodeficient mice for 8-10 wk. To ensure that the observations were not peculiar to mice, a similar trial was conducted in weanling pigs over 21 d. Tissue fatty acid composition was assessed by gas-liquid chromatography.Results: In comparison with controls, there was an increase in cis-9, trans-11 CLA in the livers of the mice and pigs after feeding with linoleic acid in combination with B. breve NCIMB 702258 (P < 0.05). In addition, an altered profile of polyunsaturated fatty acid composition was observed, including higher concentrations of the omega-3 (n-3) fatty acids eicosapentaenoic acid and docosahexaenoic acid in adipose tissue (P < 0.05). These changes were associated with reductions in the proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma (P < 0.05).Conclusions: These results are consistent with the concept that the metabolome is a composite of host and microbe metabolic activity and that the influence of the microbiota on host fatty acid composition can be manipulated by oral administration of CLA-producing microorganisms.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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By the university: Örebro University

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