WFRF:(Olerud Johan)
Sökning: WFRF:(Olerud Johan) > Sustained Beta-Cell...
- 1 av 30
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03466naa a2200337 4500 | |
| 001 | oai:DiVA.org:uu-185499 | |
| 003 | SwePub | |
| 008 | 121126s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1854992 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00474512 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Drott, Carl Johanu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)cardr171 |
| 245 | 1 0 | a Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice |
| 264 | c 2012-10-19 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2012 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Pancreatic islet endothelial cells have in recent years been shown to support beta-cell mass and function by paracrine interactions. Recently, we identified an islets endothelial-specific glycoprotein, thrombospondin-1 (TSP-1), that showed to be of importance for islet angiogenesis and beta-cell function in young mice. The present study aimed to investigate long-term consequences for islet morphology and beta-cell function of TSP-1 deficiency. Islet and beta-cell mass were observed increased at 10-12 weeks of age in TSP-1 deficient mice, but were normalized before 16 weeks of age when compared to wild-type controls. Islet vascularity was normal in 10-12 and 16-week-old TSP-1 deficient animals, whereas islets of one-year-old animals lacking TSP-1 were hypervascular. Beta-cell dysfunction in TSP-1 deficient animals was present at similar magnitudes between 10-12 and 52 weeks of age, as evaluated by glucose tolerance tests. The insulin secretion capacity in vivo of islets in one-year-old TSP-1 deficient animals was only similar to 15% of that in wild-type animals. Using a transplantation model, we reconstituted TSP-1 in adult TSP-deficient islets. In contrast to neonatal TSP-1 deficient islets that we previously reported to regain function after TSP-1 reconstitution, adult islets failed to recover. We conclude that TSP-1 deficiency in islets causes changing vascular and endocrine morphological alterations postnatally, but is coupled to a chronic beta-cell dysfunction. The beta-cell dysfunction induced by TSP-1 deficiency is irreversible if not substituted early in life. | |
| 700 | 1 | a Olerud, Johanu Uppsala universitet,Klinisk immunologi,Korsgren4 aut0 (Swepub:uu)joole425 |
| 700 | 1 | a Emanuelsson, Hannau Uppsala universitet,Molekylär och morfologisk patologi,Pontén4 aut0 (Swepub:uu)hanem153 |
| 700 | 1 | a Christoffersson, Gustavu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)guchr179 |
| 700 | 1 | a Carlsson, Per-Olau Uppsala universitet,Institutionen för medicinsk cellbiologi,Endokrin diabetes och metabolism4 aut0 (Swepub:uu)perocarl |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 7:10, s. e47451-q 7:10<e47451-x 1932-6203 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:572212/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047451&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185499 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0047451 |
- 1 av 30
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Drott, Carl Joha ...
- Olerud, Johan
- Emanuelsson, Han ...
- Christoffersson, ...
- Carlsson, Per-Ol ...
- Artiklar i publikationen
- PLOS ONE
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
