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Appropriate Time fo...
Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test
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- Hjelmevoll, Stig Ove (author)
- Departments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
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- Olsen, Merethe Elise (author)
- Departments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
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- Sollid, Johanna U. Ericson (author)
- Department of Microbiology and Virology, Institute of Medical Biology, University Hospital of North Norway, Tromsø, Norway
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- Haaheim, Hakon (author)
- Departments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
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- Melby, Kjetil K. (author)
- Department of Microbiology, Oslo University Hospital Ullevål, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway
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- Moi, Harald (author)
- Olafiaklinikken, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway
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- Unemo, Magnus, 1970- (author)
- Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sverige; Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden
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- Skogen, Vegard (author)
- Departments of Infectious Diseases, Medical Clinic, University Hospital of North Norway, Tromsø, Norway; Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
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(creator_code:org_t)
- Uppsala : Acta Dermato-Venereologica, 2012
- 2012
- English.
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In: Acta Dermato-Venereologica. - Uppsala : Acta Dermato-Venereologica. - 0001-5555 .- 1651-2057. ; 92:3, s. 316-319
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Abstract
Subject headings
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- Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg x 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive strains were resistant to ciprofloxacin. Thus, the recommended empirical treatment with ciprofloxacin in Norway should be changed immediately. TOC can be performed 2 weeks after treatment when NAATs are used for diagnosis of gonorrhoea.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- TOC
- test-of-cure
- N. gonorrhoeae
- PCR
- NAAT
Publication and Content Type
- ref (subject category)
- art (subject category)
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