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Sökning: WFRF:(Olsson Margaretha) > (2015-2019) > A validated gene re...

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FältnamnIndikatorerMetadata
00011330naa a2200793 4500
001oai:DiVA.org:liu-123522
003SwePub
008151221s2015 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-77098
009oai:prod.swepub.kib.ki.se:132482880
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1235222 URI
0247 a https://doi.org/10.1126/scitranslmed.aad27222 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-770982 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1324828802 URI
040 a (SwePub)liud (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gustafsson, Mikau Linköpings universitet,Bioinformatik,Tekniska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden; Bioinformatics, Department of Physics, Chemistry, and Biology, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)mikgu75
2451 0a A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases
264 1b AMER ASSOC ADVANCEMENT SCIENCE,c 2015
338 a electronic2 rdacarrier
500 a Funding Agencies|Cancer fund, Swedish Medical Research Council [K2013-61X-22310-01-04, 2012-3168]; Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research [250114]; Sigrid Juselius Foundation; Generalitat de Catalunya AGAUR [2014-SGR364]; Spanish Association Against Cancer; Spanish Ministry of Health ISCIII FIS [PI12/01528]; RTICC [RD12/0036/0008]
520 a Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally present after they are symptomatic. We hypothesized that early regulators of T cell-associated diseases could be found by identifying upstream transcription factors (TFs) in T cell differentiation and by prioritizing hub TFs that were enriched for disease-associated polymorphisms. A gene regulatory network (GRN) was constructed by time series profiling of the transcriptomes and methylomes of human CD4(+) T cells during in vitro differentiation into four helper T cell lineages, in combination with sequence-based TF binding predictions. The TFs GATA3, MAF, and MYB were identified as early regulators and validated by ChIP-seq (chromatin immunoprecipitation sequencing) and small interfering RNA knockdowns. Differential mRNA expression of the TFs and their targets in T cell-associated diseases supports their clinical relevance. To directly test if the TFs were altered early in disease, T cells from patients with two T cell-mediated diseases, multiple sclerosis and seasonal allergic rhinitis, were analyzed. Strikingly, the TFs were differentially expressed during asymptomatic stages of both diseases, whereas their targets showed altered expression during symptomatic stages. This analytical strategy to identify early regulators of disease by combining GRNs with genome-wide association studies may be generally applicable for functional and clinical studies of early disease development.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Gawel, Danutau Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)danga10
7001 a Alfredsson, Larsu Karolinska Institutet4 aut
7001 a Baranzini, Sergiou University of Calif San Francisco, CA, USA,Department of Neurology, University of California, San Francisco, CA, USA4 aut
7001 a Bjorkander, Janneu Futurum-Academy for Health and Care, County Council of Jönköping, Jönköping, Sweden4 aut
7001 a Blomgran, Robertu Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)robbl96
7001 a Hellberg, Sandrau Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Department of Clinical and Experimental Medicine, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)sanhe13
7001 a Eklund, Danielu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Department of Clinical Immunology and Transfusion Medicine, Linköping University, Linköping, Sweden4 aut0 (Swepub:oru)ded
7001 a Ernerudh, Janu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin,Department of Clinical and Experimental Medicine, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation, Linköping University, Linköping, Sweden; Department of Clinical Immunology and Transfusion Medicine, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)janer15
7001 a Kockum, Ingridu Karolinska Institutet4 aut
7001 a Konstantinell, Aelitau Linköpings universitet,Medicinska fakulteten,Avdelningen för kliniska vetenskaper,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden; Department of Medical Biology, The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Lahesmaa, Riitau Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Lentini, Antoniou Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)antle32
7001 a Liljenström, H. Robert I.u Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut
7001 a Mattson, Linau Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut
7001 a Matussek, Andreasu Futurum-Academy for Health and Care, County Council of Jönköping, Jönköping, Sweden4 aut
7001 a Mellergård, Johanu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)johme15
7001 a Mendez, Melissau University of Peruana Cayetano Heredia, Peru,Laboratorio de Investigación en Enfermedades Infecciosas, LID, Universidad Peruana Cayetano Heredia, Lima, Peru4 aut
7001 a Olsson, Tomasu Karolinska Institutet4 aut
7001 a Pujana, Miguel A.u Catalan Institute Oncol, Spain,Program Against Cancer Therapeutic Resistance (ProCURE), Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain4 aut
7001 a Rasool, Omidu Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Serra-Musach, Jordiu Catalan Institute Oncol, Spain,Program Against Cancer Therapeutic Resistance (ProCURE), Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain4 aut
7001 a Stenmarker, Margarethau Futurum-Academy for Health and Care, County Council of Jönköping, Jönköping, Sweden4 aut
7001 a Tripathi, Subhashu Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Viitala, Mirou Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Wang, Huiu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,University of Texas MD Anderson Cancer Centre, TX 77030 USA,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden; Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA4 aut0 (Swepub:liu)huiwa84
7001 a Zhang, Huanu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)huazh47
7001 a Nestor, Colmu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)colne37
7001 a Benson, Mikaelu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Allergicentrum US,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden4 aut0 (Swepub:liu)mikbe05
7102 a Linköpings universitetb Bioinformatik4 org
7730 t Science Translational Medicined : AMER ASSOC ADVANCEMENT SCIENCEg 7:313q 7:313x 1946-6234x 1946-6242
8564 u https://liu.diva-portal.org/smash/get/diva2:886275/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
8564 u http://liu.diva-portal.org/smash/get/diva2:886275/FULLTEXT01
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-123522
8564 8u https://doi.org/10.1126/scitranslmed.aad2722
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77098
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132482880

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