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Sökning: WFRF:(Ossler W) > (2021) > Genetic risk for bi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004608naa a2200589 4500
001oai:gup.ub.gu.se/307629
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147291276
0247 a https://gup.ub.gu.se/publication/3076292 URI
0247 a https://doi.org/10.1503/jpn.2001652 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1472912762 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Abe, C.u Karolinska Institutet4 aut
2451 0a Genetic risk for bipolar disorder and schizophrenia predicts structure and function of the ventromedial prefrontal cortex
264 c 2021-07-01
264 1b CMA Joule Inc.c 2021
520 a Background: Bipolar disorder is highly heritable and polygenic. The polygenic risk for bipolar disorder overlaps with that of schizophrenia, and polygenic scores are normally distributed in the population. Bipolar disorder has been associated with structural brain abnormalities, but it is unknown how these are linked to genetic risk factors for psychotic disorders. Methods: We tested whether polygenic risk scores for bipolar disorder and schizophrenia predict structural brain alterations in 98 patients with bipolar disorder and 81 healthy controls. We derived brain cortical thickness, surface area and volume from structural MRI scans. In post-hoc analyses, we correlated polygenic risk with functional hub strength, derived from resting-state functional MRI and brain connectomics. Results: Higher polygenic risk scores for both bipolar disorder and schizophrenia were associated with a thinner ventromedial prefrontal cortex (vmPFC). We found these associations in the combined group, and separately in patients and drug-naive controls. Polygenic risk for bipolar disorder was correlated with the functional hub strength of the vmPFC within the default mode network. Limitations: Polygenic risk is a cumulative measure of genomic burden. Detailed genetic mechanisms underlying brain alterations and their cognitive consequences still need to be determined. Conclusion: Our multimodal neuroimaging study linked genomic burden and brain endophenotype by demonstrating an association between polygenic risk scores for bipolar disorder and schizophrenia and the structure and function of the vmPFC. Our findings suggest that genetic factors might confer risk for psychotic disorders by influencing the integrity of the vmPFC, a brain region involved in self-referential processes and emotional regulation. Our study may also provide an imaging-genetics vulnerability marker that can be used to help identify individuals at risk for developing bipolar disorder.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a human cerebral-cortex
653 a surface-based analysis
653 a cortical thickness
653 a association
653 a network
653 a self
653 a mri
653 a segmentation
653 a variants
653 a area
653 a Neurosciences & Neurology
653 a Psychiatry
7001 a Petrovic, P.u Karolinska Institutet4 aut
7001 a Ossler, W.4 aut
7001 a Thompson, William Hedley,d 1987u Karolinska Institutet4 aut0 (Swepub:gu)xthowi
7001 a Liberg, B.4 aut
7001 a Song, J.u Karolinska Institutet4 aut
7001 a Bergen, S. E.u Karolinska Institutet4 aut
7001 a Sellgren, C. M.u Karolinska Institutet4 aut
7001 a Fransson, P.4 aut
7001 a Ingvar, M.u Karolinska Institutet4 aut
7001 a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
7102 a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Journal of Psychiatry & Neuroscienced : CMA Joule Inc.g 46:4q 46:4x 1180-4882x 1488-2434
8564 u https://www.jpn.ca/content/jpn/46/4/E441.full.pdf
8564 8u https://gup.ub.gu.se/publication/307629
8564 8u https://doi.org/10.1503/jpn.200165
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147291276

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