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Prevention of recurrent spontaneous abortion by intravenous immunoglobulin : a double-blind placebo-controlled study

Jablonowska, Barbara, 1948- (author)
Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
Selbing, Anders, 1946- (author)
Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
Palfi, Miodrag (author)
Linköpings universitet,Östergötlands Läns Landsting,Klinisk immunologi och transfusionsmedicin,Hälsouniversitetet
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Ernerudh, Jan, 1952- (author)
Linköpings universitet,Östergötlands Läns Landsting,Klinisk immunologi och transfusionsmedicin,Hälsouniversitetet
Kjellberg, Svante, 1946- (author)
Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
Lindton, B (author)
Department of Obstetrics and Gynecology, Huddinge University Hospital, Huddinge, Sweden
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 (creator_code:org_t)
Oxford University Press (OUP), 1999
1999
English.
In: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 14:3, s. 838-841
  • Journal article (peer-reviewed)
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  • The aim of this study was to evaluate the therapeutic efficacy of intravenous immunoglobulin (IVIG) in the prevention of recurrent spontaneous abortion (RSA). In a double-blind, randomized, placebo-controlled study, 41 women with a history of unexplained recurrent spontaneous abortion were treated with IVIG or saline infusions during pregnancy. The birth of a child was considered a successful outcome. The overall success rate was 77% in the IVIG group compared with 79% in the placebo group. For women with primary RSA the success rates were 82 (IVIG) and 89% (placebo), and for women with secondary RSA the rates were 73 (IVIG) and 70% (placebo). We found no statistically significant difference in treatment results between IVIG and placebo.

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