WFRF:(Palmqvist Karin)
Search: WFRF:(Palmqvist Karin) > (2020-2024) > The Relationship be...
- 1 of 11
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04168naa a2200457 4500 | |
| 001 | oai:DiVA.org:umu-190660 | |
| 003 | SwePub | |
| 008 | 211221s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1906602 URI |
| 024 | 7 | a https://doi.org/10.1159/0005183972 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Beilmann-Lehtonen, Ines4 aut |
| 245 | 1 0 | a The Relationship between the Tissue Expression of TLR2, TLR4, TLR5, and TLR7 and Systemic Inflammatory Responses in Colorectal Cancer Patients |
| 264 | c 2021-09-08 | |
| 264 | 1 | b S. Karger,c 2021 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive protein (CRP) levels exhibit compromised prognoses. Toll-like receptors (TLRs), activating the innate and adaptive immune systems, may contribute to pro- and antitumorigenic inflammatory responses. We aimed to identify a possible link between local and systemic inflammatory responses in CRC patients by investigating the association between tissue TLRs and plasma CRP.Methods: Tissue expressions of TLR2, TLR4, TLR5, and TLR7 were assessed using immunohistochemistry of tissue microarray slides from 549 CRC patients surgically treated between 1998 and 2005. Blood samples were drawn preoperatively, centrifuged, aliquoted, and stored at −80°C until analysis. Plasma CRP was determined through high-sensitivity time-resolved immunofluorometric assay. We investigated the association of TLRs to clinicopathologic variables, plasma CRP, and survival.Results: High TLR2 expression (hazard ratio [HR] 0.59; 95% confidence interval [CI] 0.41–0.85; p = 0.005), high TLR5 expression (HR 0.60; 95% CI 0.45–0.83; p = 0.002), positive TLR7 expression (HR 0.49; 95% CI 0.33–0.72; p < 0.001), and low CRP (HR 1.48; 95% CI 1.08–2.11; p = 0.017) were associated with a better prognosis. A high TLR2 immunoexpression was associated with a better prognosis among low-CRP patients (HR 0.53; 95% CI 0.35–0.80; p = 0.002), high TLR4 expression among high-CRP patients (HR 2.04; 95% CI 1.04–4.00; p = 0.038), high TLR5 expression among low-CRP patients (HR 0.059; 95% CI 0.37–0.92; p = 0.021), and positive TLR7 expression among low-CRP patients (HR 0.53; 95% CI 0.28–1.00; p = 0.049). In multivariate analyses, no biomarkers emerged as significant independent variables.Conclusions: High tissue TLR2, TLR5, and TLR7 levels were associated with a better prognosis. Among low-CRP patients, those with high TLR2, TLR5, and TLR7 immunoexpressions exhibited a better prognosis. Among high CRP patients, a high TLR4 immunoexpression was associated with a better prognosis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Colorectal cancer | |
| 653 | a Immunohistochemistry | |
| 653 | a Prognosis | |
| 653 | a Survival | |
| 653 | a Toll-like receptor | |
| 700 | 1 | a Hagström, Jaana4 aut |
| 700 | 1 | a Kaprio, Tuomas4 aut |
| 700 | 1 | a Stenman, Ulf-Håkan4 aut |
| 700 | 1 | a Strigård, Karinu Umeå universitet,Kirurgi,Clister4 aut0 (Swepub:umu)kast0065 |
| 700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
| 700 | 1 | a Gunnarsson, Ulfu Umeå universitet,Kirurgi,Clister4 aut0 (Swepub:umu)ulgu0014 |
| 700 | 1 | a Böckelman, Camilla4 aut |
| 700 | 1 | a Haglund, Caj4 aut |
| 710 | 2 | a Umeå universitetb Kirurgi4 org |
| 773 | 0 | t Oncologyd : S. Kargerg 99:12, s. 790-801q 99:12<790-801x 0030-2414x 1423-0232 |
| 856 | 4 | u https://helda.helsinki.fi/bitstream/10138/338688/1/The_Relationship_Between_the_Tissue_Expression_of_TLR2_TLR4_TLR5_and_TLR7_and_Systemic_Inflammatory_Responses_in_Colorectal_Cancer_Patients_.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190660 |
| 856 | 4 8 | u https://doi.org/10.1159/000518397 |
- 1 of 11
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Beilmann-Lehtone ...
- Hagström, Jaana
- Kaprio, Tuomas
- Stenman, Ulf-Håk ...
- Strigård, Karin
- Palmqvist, Richa ...
- show more...
- Gunnarsson, Ulf
- Böckelman, Camil ...
- Haglund, Caj
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Oncology
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
