Anticorrosive evaluation of an environmentally benign chromone-thiazole hybrid with excellent anticancer activity

Kumar Sharma, Manish (author): Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana

Parashar, Sonia (author): Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohar, Rohtak 124001, Haryana, India, Haryana

Sharma, Deepak (author): Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana

Jakhar, Kranti (author): Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana

Sihmar, Ashish (author): Department of Chemistry, Maharshi Dayanand University, Rohtak 124001, Haryana, India, Haryana

Kumar, Suresh (author): Department of Chemistry, Chaudhary Devi Lal University, Sirsa 125055, Haryana, India, Haryana

Jhaa, Gaurav (author): Department of Chemistry, Chemical Information Sciences Laboratory, Pondicherry University, Puducherry 605014, India, Puducherry

Dahiya, Hariom (author): Department of Chemistry, Maharshi Dayanand University, Rohtak 124001, Haryana, India, Haryana

Lal, Kashmiri (author): Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India, Haryana

Om, Hari (author): Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana

(creator_code:org_t)

Elsevier B.V. 2024
2024
English.
In: Journal of Molecular Liquids. - : Elsevier B.V.. - 0167-7322 .- 1873-3166. ; 405

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

The research article comprehensively presents salient applications of an environment friendly chromone-thiazole hybrid (CTH) as a potential anticancer molecule and as an organic inhibitor against mild steel (MS) corrosion. The SRB assay used for antiproliferative screening gives excellent IC50 (10.8 μM) against MDA-MB-231 (breast cancer) cell line. Further, CTH has excellent inhibition efficacy (∼97 % at 400 ppm) against MS corrosion in 1 M HCl. The in vitro results of anticancer and anticorrosive evaluation are in good agreement with the computational studies, which include docking, ADME, DFT, MD simulation, and toxicity prediction.

By the author/editor: Kumar Sharma, Ma ...; Parashar, Sonia; Sharma, Deepak; Jakhar, Kranti; Sihmar, Ashish; Kumar, Suresh; show more...; Jhaa, Gaurav; Dahiya, Hariom; Bhardwaj, Anand; Lal, Kashmiri; Om, Hari; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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