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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004079naa a2200697 4500
001oai:gup.ub.gu.se/82183
003SwePub
008240528s2008 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/821832 URI
0247 a https://doi.org/10.1016/j.bbmt.2008.06.0202 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pasquini, Ricardo4 aut
2451 0a HLA-matched sibling hematopoietic stem cell transplantation for fanconi anemia: comparison of irradiation and nonirradiation containing conditioning regimens.
264 1b Elsevier BV,c 2008
520 a Related to the underlying DNA repair defect that is the hallmark of Fanconi anemia (FA), preparatory regimen-related toxicities have been obstacles to hematopoietic cell transplantation (HCT). In an attempt to decrease the risk and severity of regimen-related toxicities, nonirradiation regimens have been explored. The aim of this study is to compare outcomes after irradiation and nonirradiation regimens in 148 FA patients and identify risk factors impacting upon HCT outcomes. Hematopoietic recovery, acute and chronic graft-versus-host disease (aGVHD, GVHD), and mortality were similar after irradiation and nonirradiation regimens. In both groups of recipients aged >10 years, prior use of androgens and cytomegalovirus seropositivity in either the donor or recipient were associated with higher mortality. With median follow-ups >5 years, the 5-year probability of overall survival, adjusted for factors impacting overall mortality was 78% and 81% after irradiation and nonirradiation regimens, P = .61. In view of the high risk of cancer and other radiation-related effects on growth and development, these results support the use of nonirradiation preparatory regimens. As the peak time for developing solid tumors after HCT is 8 to 9 years, longer follow-up is required before definitive statements can be made regarding the impact of nonirradiation regimens on cancer risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Adolescent
653 a Adult
653 a Fanconi Anemia
653 a therapy
653 a Female
653 a Graft vs Host Disease
653 a Hematopoiesis
653 a Hematopoietic Stem Cell Transplantation
653 a methods
653 a mortality
653 a Histocompatibility Testing
653 a Humans
653 a Male
653 a Radiotherapy
653 a Registries
653 a Retrospective Studies
653 a Risk Factors
653 a Siblings
653 a Survival Analysis
653 a Transplantation Conditioning
653 a methods
653 a standards
653 a Treatment Outcome
7001 a Carreras, Jeanette4 aut
7001 a Pasquini, Marcelo C4 aut
7001 a Camitta, Bruce M4 aut
7001 a Fasth, Anders,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xfasan
7001 a Hale, Gregory A4 aut
7001 a Harris, Richard E4 aut
7001 a Marsh, Judith C4 aut
7001 a Robinson, Anibal J4 aut
7001 a Zhang, Mei-Jie4 aut
7001 a Eapen, Mary4 aut
7001 a Wagner, John E4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper4 org
7730 t Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantationd : Elsevier BVg 14:10, s. 1141-7q 14:10<1141-7x 1523-6536
7730 t Biology of Blood and Marrow Transplantationd : Elsevier BVg 14:10, s. 1141-7q 14:10<1141-7x 1083-8791
8564 u https://doi.org/10.1016/j.bbmt.2008.06.020
8564 8u https://gup.ub.gu.se/publication/82183
8564 8u https://doi.org/10.1016/j.bbmt.2008.06.020

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