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Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis.

Pauli, Gabrielle (author)
Larsen, Tina H (author)
Rak, Sabina, 1945 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Horak, Friedrich (author)
Pastorello, Elide (author)
Valenta, Rudolph (author)
Purohit, Ashok (author)
Arvidsson, Monica, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
Kavina, Alexander (author)
Schroeder, Jan W (author)
Mothes, Nadine (author)
Spitzauer, Susanne (author)
Montagut, Armelle (author)
Galvain, Sylvie (author)
Melac, Michel (author)
André, Claude (author)
Poulsen, Lars K (author)
Malling, Hans-Jorgen (author)
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 (creator_code:org_t)
Elsevier BV, 2008
2008
English.
In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 122:5, s. 951-60
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition. OBJECTIVE: To evaluate the effectiveness of a new recombinant birch pollen allergen vaccine in patients with birch pollen allergy. METHODS: A multicenter, randomized, double-blind, placebo-controlled trial was undertaken to compare the following 3 vaccines in 134 adults with birch pollen allergy: recombinant birch pollen allergen vaccine (rBet v 1a), licensed birch pollen extract, natural purified birch pollen allergen (nBet v 1), and placebo. Patients received 12 weekly injections followed by monthly injections of the maintenance dose containing 15 microg Bet v 1 for 2 years. RESULTS: Significant reductions (about 50%) in rhinoconjunctivitis symptoms (rBet v 1, P = .0002; nBet v 1, P = .0006; birch extract, P = .0024), rescue medication (rBet v 1, P = .0011; nBet v 1, P = .0025; birch extract, P = .0063), and skin sensitivities (P < .0001) were observed in the 3 actively treated groups compared with placebo during 2 consecutive pollen seasons. Clinical improvement was accompanied by marked increases in Bet v 1-specific IgG levels, which were higher in the rBet v 1-treated group than in the birch and nBet v 1-treated groups. New IgE specificities were induced in 3 of 29 patients treated with birch pollen extract, but in none of the 32 rBet v 1-treated or 29 nBet v 1-treated patients. No severe systemic adverse events were observed in the rBet v 1-treated group. CONCLUSION: The rBet v 1-based vaccine was safe and effective in treating birch pollen allergy, and induced a highly specific immune response.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Keyword

Adult
Allergens
adverse effects
immunology
Anti-Allergic Agents
therapeutic use
Betula
adverse effects
immunology
Conjunctivitis
Allergic
immunology
therapy
Desensitization
Immunologic
Double-Blind Method
Female
Humans
Male
Middle Aged
Pollen
adverse effects
immunology
Recombinant Proteins
immunology
therapeutic use
Rhinitis
Allergic
Seasonal
immunology
therapy
Vaccines
immunology
therapeutic use
Young Adult

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