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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03862naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:b5da7c3c-ffb1-4b07-8e43-0c1b1fc2f0e0 | |
| 003 | SwePub | |
| 008 | 160401s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/29065062 URI |
| 024 | 7 | a https://doi.org/10.1002/hep.255422 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Volarevic, Vladislav4 aut |
| 245 | 1 0 | a Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice |
| 264 | c 2012-04-25 | |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2012 |
| 520 | a We used concanavalin A (Con A)-induced liver injury to study the role of galectin-3 (Gal-3) in the induction of inflammatory pathology and hepatocellular damage. We tested susceptibility to Con Ainduced hepatitis in galectin-3-deficient (Gal-3-/-) mice and analyzed the effects of pretreatment with a selective inhibitor of Gal-3 (TD139) in wild-type (WT) C57BL/6 mice, as evaluated by a liver enzyme test, quantitative histology, mononuclear cell (MNC) infiltration, cytokine production, intracellular staining of immune cells, and percentage of apoptotic MNCs in the liver. Gal-3-/- mice were less sensitive to Con Ainduced hepatitis and had a significantly lower number of activated lymphoid and dendritic cells (DCs) in the liver. The level of tumor necrosis factor alpha (TNFa), interferon gamma (IFN?), and interleukin (IL)-17 and -4 in the sera and the number of TNFa-, IFN?-, and IL-17- and -4-producing cluster of differentiation (CD)4+ cells as well as IL-12-producing CD11c+ DCs were lower, whereas the number of IL-10-producing CD4+ T cells and F4/80+ macrophages were significantly higher in livers of Gal-3-/- mice. Significantly higher percentages of late apoptotic Annexin V+ propidium-idodide+ liver-infiltrating MNCs and splenocytes were observed in Gal-3-/- mice, compared to WT mice. Pretreatment of WT C57BL/6 mice with TD139 led to the attenuation of liver injury and milder infiltration of IFN?- and IL-17- and -4-producing CD4+ T cells, as well as an increase in the total number of IL-10-producing CD4+ T cells and F4/80+ CD206+ alternatively activated macrophages and prevented the apoptosis of liver-infiltrating MNCs. Conclusions: Gal-3 plays an important proinflammatory role in Con Ainduced hepatitis by promoting the activation of T lymphocytes and natural killer T cells, maturation of DCs, secretion of proinflammatory cytokines, down-regulation of M2 macrophage polarization, and apoptosis of MNCs in the liver. (HEPATOLOGY 2012;55:19541964) | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 700 | 1 | a Milovanovic, Marija4 aut |
| 700 | 1 | a Ljujic, Biljana4 aut |
| 700 | 1 | a Pejnovic, Nada4 aut |
| 700 | 1 | a Arsenijevic, Nebojsa4 aut |
| 700 | 1 | a Nilsson, Ulfu Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ok2-uni |
| 700 | 1 | a Leffler, Hakon4 aut |
| 700 | 1 | a Lukic, Miodrag L.4 aut |
| 710 | 2 | a Centrum för analys och syntesb Kemiska institutionen4 org |
| 773 | 0 | t Hepatologyd : Ovid Technologies (Wolters Kluwer Health)g 55:6, s. 1954-1964q 55:6<1954-1964x 1527-3350x 0270-9139 |
| 856 | 4 | u http://dx.doi.org/10.1002/hep.25542y FULLTEXT |
| 856 | 4 | u https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25542 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2906506 |
| 856 | 4 8 | u https://doi.org/10.1002/hep.25542 |
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