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Different Periampul...
Different Periampullary Types and Subtypes Leading to Different Perioperative Outcomes of Pancreatoduodenectomy: Reality and Not a Myth; An International Multicenter Cohort Study
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- Uijterwijk, Bas A. (författare)
- Fdn Poliambulanza, Italy; Univ Amsterdam, Netherlands; Canc Ctr Amsterdam, Netherlands,Dept Surg, WA 98101 USA
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- Lemmers, Daniel H. (författare)
- Fdn Poliambulanza, Italy; Univ Amsterdam, Netherlands; Canc Ctr Amsterdam, Netherlands
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- Fusai, Giuseppe Kito (författare)
- Royal Free London NHS Fdn Trust, England
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- Koerkamp, Bas Groot (författare)
- Erasmus MC, Netherlands
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- Koek, Sharnice (författare)
- Fiona Stanley Hosp, Australia
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- Zerbi, Alessandro (författare)
- IRCCS Humanitas Res Hosp, Italy
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- Sparrelid, Ernesto (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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- Boggi, Ugo (författare)
- Univ Pisa, Italy
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- Luyer, Misha (författare)
- Catharina Hosp, Netherlands
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- Ielpo, Benedetto (författare)
- Hosp Mar, Spain
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- Salvia, Roberto (författare)
- Univ Hosp Verona, Italy
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- Goh, Brian K. P. (författare)
- Singapore Gen Hosp, Singapore; Duke Natl Univ, Singapore,Nouvel Hop Civil NHC, France
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- Kazemier, Geert (författare)
- Dept Surg, Netherlands
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- Björnsson, Bergthor (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Serradilla-Martin, Mario (författare)
- Miguel Servet Univ Hosp, Spain
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- Mazzola, Michele (författare)
- ASST Grande Osped Metropolitano Niguarda, Italy
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- Mavroeidis, Vasileios K. (författare)
- Royal Marsden Hosp, England; Oxford Univ Hosp NHS Fdn Trust, England
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- Sanchez-Cabus, Santiago (författare)
- Hosp Santa Creu & Sant Pau, Spain
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- Pessaux, Patrick (författare)
- Nouvel Hop Civil NHC, France
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- White, Steven (författare)
- Newcastle Tyne Hosp, England
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- Alseidi, Adnan (författare)
- Dept Surg, WA 98101 USA
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- Valle, Raffaele Dalla (författare)
- Univ Hosp Parma, Italy
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- Korkolis, Dimitris (författare)
- Hellen Anticanc Hosp St Savvas, Greece
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- Bolm, Louisa R. (författare)
- Univ Med Ctr Schleswig Holstein, Germany
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- Soonawalla, Zahir (författare)
- Oxford Univ Hosp NHS Fdn Trust, England
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- Roberts, Keith J. (författare)
- Univ Birmingham, England
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- Vladimirov, Miljana (författare)
- Dept Surg Hosp Nuremberg, Germany
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- Mazzotta, Alessandro (författare)
- Inst Mutualiste Montsouris, France
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- Kleeff, Jorg (författare)
- Martin Luther Univ Halle Wittenberg, Germany
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- Suarez Munoz, Miguel Angel (författare)
- Univ Hosp Virgen Victoria, Spain
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- Besselink, Marc G. (författare)
- Univ Amsterdam, Netherlands
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- Hilal, Mohammed Abu (författare)
- Fdn Poliambulanza, Italy
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(creator_code:org_t)
- MDPI, 2024
- 2024
- Engelska.
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 16:5
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Simple Summary: For cancer in the periampullary region, surgical resection with pancreatoduodenectomy remains the main curative treatment. Variations in prognosis suggest distinct growth patterns and tissue reactions, potentially influencing complications and perioperative mortality. This study aims to explore the impact of the type of periampullary adenocarcinoma on the perioperative hospital course. This international multicenter cohort study included 30 centers. Patients with duodenal adenocarcinoma (DAC), intestinal-type (AmpIT) and pancreatobiliary-type (AmpPB) ampullary adenocarcinoma, distal cholangiocarcinoma (dCCA), and pancreatic ductal adenocarcinoma (PDAC) were included. The primary outcome was 30-day or in-hospital mortality, and secondary outcomes were major morbidity (Clavien-Dindo 3b >=), clinically relevant post-operative pancreatic fistula (CR-POPF), and length of hospital stay (LOS). Results: Overall, 3622 patients were included in the study (370 DAC, 811 AmpIT, 895 AmpPB, 1083 dCCA, and 463 PDAC). Mortality rates were comparable between DAC, AmpIT, AmpPB, and dCCA (ranging from 3.7% to 5.9%), while lower for PDAC (1.5%, p = 0.013). Major morbidity rate was the lowest in PDAC (4.4%) and the highest for DAC (19.9%, p < 0.001). The highest rates of CR-POPF were observed in DAC (27.3%), AmpIT (25.5%), and dCCA (27.6%), which were significantly higher compared to AmpPB (18.5%, p = 0.001) and PDAC (8.3%, p < 0.001). The shortest LOS was found in PDAC (11 d vs. 14-15 d, p < 0.001). Discussion: In conclusion, this study shows significant variations in perioperative mortality, post-operative complications, and hospital stay among different periampullary cancers, and between the ampullary subtypes. Further research should assess the biological characteristics and tissue reactions associated with each type of periampullary cancer, including subtypes, in order to improve patient management and personalized treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- non-pancreatic periampullary cancer; complications; pancreatoduodenectomy; tumor behavior
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- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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Uijterwijk, Bas ...
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Lemmers, Daniel ...
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Fusai, Giuseppe ...
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Koerkamp, Bas Gr ...
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Koek, Sharnice
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Zerbi, Alessandr ...
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visa fler...
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Sparrelid, Ernes ...
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Boggi, Ugo
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Luyer, Misha
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Ielpo, Benedetto
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Salvia, Roberto
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Goh, Brian K. P.
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Kazemier, Geert
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Björnsson, Bergt ...
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Serradilla-Marti ...
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Mazzola, Michele
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Mavroeidis, Vasi ...
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Sanchez-Cabus, S ...
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Pessaux, Patrick
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White, Steven
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Alseidi, Adnan
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Valle, Raffaele ...
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Korkolis, Dimitr ...
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Bolm, Louisa R.
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Soonawalla, Zahi ...
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Roberts, Keith J ...
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Vladimirov, Milj ...
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Mazzotta, Alessa ...
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Kleeff, Jorg
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Suarez Munoz, Mi ...
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Besselink, Marc ...
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Hilal, Mohammed ...
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