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Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome - an iBFM-SG study.
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- Forestier, Erik (author)
- Umeå universitet,Pediatrik
- Izraeli, Shai (author)
- Beverloo, Berna (author)
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- Haas, Oskar (author)
- Pession, Andrea (author)
- Michalova, Kyra (author)
- Stark, Batia (author)
- Harrison, Christine J (author)
- Teigler-Schlegel, Andrea (author)
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- (creator_code:org_t)
- American Society of Hematology, 2007
- 2007
- English.
- In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020.
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Children with Down syndrome (DS) have a markedly increased risk of acute lymphoblastic and myeloid leukemias (ALL+AML). To identify chromosomal changes cooperating with +21 that may provide information on the pathogenesis of these leukemias, we analyzed 215 DS-ALL and 189 DS-AML. Unlike previous smaller series, a significant proportion of DS-ALL had the typical B-cell precursor ALL abnormalities high hyperdiploidy (HeH; 11%) and t(12;21)(p13;q22) (10%). The HeH DS-ALL were characterized by gains of the same chromosomes as non-DS-HeH, suggesting the same etiology/pathogenesis. In addition, specific genetic subtypes of DS-ALL were suggested by the significant overrepresentation of cases with +X, t(8;14)(q11;q32), and del(9p). Unlike DS-ALL, the common translocations associated with non-DS-AML were rare in DS-AML, which instead were characterized by the frequent presence of dup(1q), del(6q), del(7p), dup(7q), +8, +11, del(16q), and +21. This series of DS leukemias - the largest to date - reveals that DS-ALL is a heterogeneous disorder that comprises both t(12;21) and HeH as well as DS-related abnormalities. Furthermore, this analysis confirms that DS-AML is a distinct entity, originating through other genetic pathways than do non-DS-AML, and suggests that unbalanced changes such as dup(1q), +8, and +21 are involved in the leukemogenic process.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Leukemia
- Down syndrome
- children
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- ref (subject category)
- art (subject category)
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- Forestier, Erik
- Izraeli, Shai
- Beverloo, Berna
- Haas, Oskar
- Pession, Andrea
- Michalova, Kyra
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- Stark, Batia
- Harrison, Christ ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Hematology
- Articles in the publication
- Blood
- By the university
- Umeå University
- Lund University
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