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Sökning: WFRF:(Pinkner J) > (2020-2022) > Ring-fused 2-pyrido...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005793naa a2200517 4500
001oai:DiVA.org:umu-201191
003SwePub
008230105s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2011912 URI
0247 a https://doi.org/10.1073/pnas.22109121192 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nye, Taylor M.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
2451 0a Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics
264 c 2022-10-17
264 1b PNAS,c 2022
338 a electronic2 rdacarrier
520 a The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone, which are active against vancomycin-resistant enterococci (VRE), a serious threat as classified by the Centers for Disease Control and Prevention, and other multidrug-resistant Gram-positive bacteria. Ring-fused 2-pyridone antibiotics have bacteriostatic activity against actively dividing exponential phase enterococcal cells and bactericidal activity against nondividing stationary phase enterococcal cells. The molecular mechanism of drug-induced killing of stationary phase cells mimics aspects of fratricide observed in enterococcal biofilms, where both are mediated by the Atn autolysin and the GelE protease. In addition, combinations of sublethal concentrations of ring-fused 2-pyridones and standard-of-care antibiotics, such as vancomycin, were found to synergize to kill clinical strains of VRE. Furthermore, a broad range of antibiotic resistant Gram-positive pathogens, including those responsible for the increasing incidence of antibiotic resistant healthcare-associated infections, are susceptible to this new class of 2-pyridone antibiotics. Given the broad antibacterial activities of ring-fused 2-pyridone compounds against Gram-positive (GmP) bacteria we term these compounds GmPcides, which hold promise in combating the rising tide of antibiotic resistant Gram-positive pathogens.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a antibiotic resistance
653 a antibiotic synergy
653 a multidrug-resistant pathogens
653 a VRE
7001 a Tükenmez, Hasan,d 1987-u Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)htak0003
7001 a Singh, Pardeepu Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)pasi0012
7001 a Flores-Mireles, Ana L.u Department of Biological Sciences, University of Notre Dame, Notre Dame, India4 aut
7001 a Obernuefemann, Chloe L.P.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
7001 a Pinkner, Jerome S.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
7001 a Sarkar, Souviku Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)sosa0089
7001 a Bonde, Mariu Umeå universitet,Kemiska institutionen,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)maiboe01
7001 a Lindgren, Anders E. G.u Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)arslin04
7001 a Dodson, Karen W.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
7001 a Johansson, Jörgenu Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)jojo0001
7001 a Almqvist, Fredriku Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)fral0001
7001 a Caparon, Michael G.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
7001 a Hultgren, Scott J.u Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United States4 aut
7102 a Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University, School of Medicine, MO, St. Louis, United Statesb Kemiska institutionen4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : PNASg 119:43q 119:43x 0027-8424x 1091-6490
8564 u https://doi.org/10.1073/pnas.2210912119y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1724104/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201191
8564 8u https://doi.org/10.1073/pnas.2210912119

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