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Sökning: WFRF:(Pipaliya Shweta V) > The Oxymonad Genome...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005608naa a2200601 4500
001oai:DiVA.org:uu-400822
003SwePub
008200113s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4008222 URI
0247 a https://doi.org/10.1093/molbev/msz1472 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Karnkowska, Annau Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic;Univ Warsaw, Fac Biol, Biol & Chem Res Ctr, Dept Mol Phylogenet & Evolut, Warsaw, Poland4 aut
2451 0a The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion
264 c 2019-08-06
264 1b OXFORD UNIV PRESS,c 2019
338 a electronic2 rdacarrier
520 a The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here, we report an extensive analysis of the M. exilis genome to address this question. Unexpectedly, we find that M. exilis genome structure and content is similar in complexity to other eukaryotes and less "reduced" than genomes of some other protists from the Metamonada group to which it belongs. Furthermore, the predicted cytoskeletal systems, the organization of endomembrane systems, and biosynthetic pathways also display canonical eukaryotic complexity. The only apparent preadaptation that permitted the loss of mitochondria was the acquisition of the SUF system for Fe-S cluster assembly and the loss of glycine cleavage system. Changes in other systems, including in amino acid metabolism and oxidative stress response, were coincident with the loss of mitochondria but are likely adaptations to the microaerophilic and endobiotic niche rather than the mitochondrial loss per se. Apart from the lack of mitochondria and peroxisomes, we show that M. exilis is a fully elaborated eukaryotic cell that is a promising model system in which eukaryotic cell biology can be investigated in the absence of mitochondria.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a amitochondrial eukaryote
653 a cell biology
653 a Monocercomonoides
653 a oxymonads
653 a protist genomics
7001 a Treitli, Sebastian C.u Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7001 a Brzon, Ondreju Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7001 a Novak, Lukasu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7001 a Vacek, Vojtechu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7001 a Soukal, Petru Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7001 a Barlow, Lael D.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut
7001 a Herman, Emily K.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut
7001 a Pipaliya, Shweta, Vu Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut
7001 a Panek, Tomasu Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut
7001 a Zihala, Davidu Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut
7001 a Petrzelkova, Romanau Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut
7001 a Butenko, Anzhelikau Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut
7001 a Eme, Laurau Uppsala universitet,Institutionen för cell- och molekylärbiologi,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut0 (Swepub:uu)lauem469
7001 a Stairs, Courtney W.u Uppsala universitet,Institutionen för cell- och molekylärbiologi,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut0 (Swepub:uu)coust885
7001 a Roger, Andrew J.u Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut
7001 a Elias, Mareku Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic;Univ Ostrava, Fac Sci, Inst Environm Technol, Ostrava, Czech Republic4 aut
7001 a Dacks, Joel B.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut
7001 a Hampl, Vladimiru Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut
7102 a Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic;Univ Warsaw, Fac Biol, Biol & Chem Res Ctr, Dept Mol Phylogenet & Evolut, Warsaw, Polandb Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 org
7730 t Molecular biology and evolutiond : OXFORD UNIV PRESSg 36:10, s. 2292-2312q 36:10<2292-2312x 0737-4038x 1537-1719
8564 u https://doi.org/10.1093/molbev/msz147y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1384938/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://academic.oup.com/mbe/article-pdf/36/10/2292/30048254/msz147.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400822
8564 8u https://doi.org/10.1093/molbev/msz147

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