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The relevance of ti...
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose
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Commins, Scott P. (författare)
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James, Hayley R. (författare)
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Kelly, Libby A. (författare)
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Pochan, Shawna L. (författare)
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Workman, Lisa J. (författare)
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Perzanowski, Matthew S. (författare)
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Kocan, Katherine M. (författare)
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Fahy, John V. (författare)
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Nganga, Lucy W. (författare)
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- Rönmark, Eva (författare)
- Umeå universitet,Yrkes- och miljömedicin
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Cooper, Philip J. (författare)
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Platts-Mills, Thomas A. E. (författare)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 127:5, s. 1286-1293.e6
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. Objectives: We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur.Methods: Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP.Results: Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (chi(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001).Conclusion: The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Ticks
- anaphylaxis
- oligosaccharide
- alpha-gal
- IgE antibody to CCD
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- art (ämneskategori)
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Commins, Scott P ...
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James, Hayley R.
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Kelly, Libby A.
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Pochan, Shawna L ...
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Workman, Lisa J.
-
Perzanowski, Mat ...
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visa fler...
-
Kocan, Katherine ...
-
Fahy, John V.
-
Nganga, Lucy W.
-
Rönmark, Eva
-
Cooper, Philip J ...
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Platts-Mills, Th ...
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