Sökning: WFRF:(Pogue Janice) > Extracranial System...
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000 | 04726naa a2200481 4500 | |
001 | oai:DiVA.org:uu-262954 | |
003 | SwePub | |
008 | 150923s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2629542 URI |
024 | 7 | a https://doi.org/10.1161/CIRCULATIONAHA.114.0132432 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bekwelem, Wobou Univ Minnesota, Sch Med, Lillehei Heart Inst, Minneapolis, MN 55455 USA.;Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA.4 aut |
245 | 1 0 | a Extracranial Systemic Embolic Events in Patients With Nonvalvular Atrial Fibrillation Incidence, Risk Factors, and Outcomes |
264 | 1 | c 2015 |
338 | a print2 rdacarrier | |
520 | a Background Nonvalvular atrial fibrillation is a major cause of thromboembolic events. In comparison with atrial fibrillation-related stroke, extracranial systemic embolic events (SEEs) remain poorly defined. Methods and Results All suspected SEEs reported among 37973 participants of 4 large contemporary randomized clinical trials of anticoagulation in atrial fibrillation were independently readjudicated for clinical and objective evidence of sudden loss of perfusion of a limb or organ. Over 91746 patient-years of follow-up, 221 SEEs occurred in 219 subjects. The SEE incidence was 0.24 of 100 and stroke incidence was 1.92 of 100 patient-years. In comparison with patients with stroke, those with SEE were more often female (56% versus 47%; P=0.01) and had comparable mean age (73.18.5 versus 73.5 +/- 8.8 years; P=0.57) and mean CHADS(2) scores (2.4 +/- 1.3 versus 2.5 +/- 1.2; P=0.33). SEEs more frequently involved the lower extremity (58%) than visceral-mesenteric (31%) or upper extremity (10%). SEE-related care involved clinic assessment alone in 5%, 30% were hospitalized without procedures, 60% underwent endovascular or surgical intervention, and 5% underwent amputation. Within 30 days, 54% of patients recovered fully, 20% survived with deficits, and 25% died. Thirty-day mortality was greater after visceral-mesenteric than lower- or upper-extremity SEE (55%, 17%, and 9%, respectively, P0.0001). The relative risk of death throughout follow-up was 4.33 (95% confidence interval, 3.29-5.70) after SEE versus 6.79 (95% confidence interval, 6.22-7.41) after stroke in comparison with patients without either event. Conclusions SEE constituted 11.5% of clinically recognized thromboembolic events in patients with atrial fibrillation and was associated with high morbidity and mortality. SEE mortality was comparable to that of ischemic stroke and varied by anatomic site. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a arrhythmias | |
653 | a cardiac | |
653 | a atrial fibrillation | |
653 | a embolism | |
653 | a peripheral artery disease | |
653 | a risk factors | |
700 | 1 | a Connolly, Stuart J.u McMaster Univ, Dept Med, Hamilton, ON, Canada.4 aut |
700 | 1 | a Halperin, Jonathan L.u Mt Sinai Sch Med, New York, NY USA.4 aut |
700 | 1 | a Adabag, Selcuku Minneapolis Vet Adm Med Ctr, Div Cardiol, Minneapolis, MN USA.4 aut |
700 | 1 | a Duval, Sueu Univ Minnesota, Sch Med, Lillehei Heart Inst, Minneapolis, MN 55455 USA.;Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Chrolavicius, Susanu McMaster Univ, Dept Med, Hamilton, ON, Canada.4 aut |
700 | 1 | a Pogue, Janiceu McMaster Univ, Dept Med, Hamilton, ON, Canada.4 aut |
700 | 1 | a Ezekowitz, Michael D.u Lankenau Inst Med Res, Wynnewood, PA USA.4 aut |
700 | 1 | a Eikelboom, John W.u McMaster Univ, Dept Med, Hamilton, ON, Canada.4 aut |
700 | 1 | a Wallentin, Larsu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall |
700 | 1 | a Yusuf, Salimu McMaster Univ, Dept Med, Hamilton, ON, Canada.4 aut |
700 | 1 | a Hirsch, Alan T.u Univ Minnesota, Sch Med, Lillehei Heart Inst, Minneapolis, MN 55455 USA.;Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA.4 aut |
710 | 2 | a Univ Minnesota, Sch Med, Lillehei Heart Inst, Minneapolis, MN 55455 USA.;Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA.b McMaster Univ, Dept Med, Hamilton, ON, Canada.4 org |
773 | 0 | t Circulationg 132:9, s. 796-803q 132:9<796-803x 0009-7322x 1524-4539 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262954 |
856 | 4 8 | u https://doi.org/10.1161/CIRCULATIONAHA.114.013243 |
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