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Direct Transcriptio...
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
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- Shlien, Adam (author)
- Wellcome Trust Sanger Institute
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- Raine, Keiran (author)
- Wellcome Trust Sanger Institute
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- Fuligni, Fabio (author)
- Hospital for Sick Children, Toronto
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- Arnold, Roland (author)
- Hospital for Sick Children, Toronto
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- Nik-Zainal, Serena (author)
- Wellcome Trust Sanger Institute
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- Dronov, Serge (author)
- Wellcome Trust Sanger Institute
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- Mamanova, Lira (author)
- Wellcome Trust Sanger Institute
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- Rosic, Andrej (author)
- Hospital for Sick Children, Toronto
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- Ju, Young Seok (author)
- Wellcome Trust Sanger Institute
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- Cooke, Susanna L. (author)
- Wellcome Trust Sanger Institute
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- Ramakrishna, Manasa (author)
- Wellcome Trust Sanger Institute
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- Papaemmanuil, Elli (author)
- Wellcome Trust Sanger Institute
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- Davies, Helen R. (author)
- Wellcome Trust Sanger Institute
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- Tarpey, Patrick S. (author)
- Wellcome Trust Sanger Institute
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- Van Loo, Peter (author)
- Catholic University of Leuven,Wellcome Trust Sanger Institute
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- Wedge, David C. (author)
- Wellcome Trust Sanger Institute
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- Jones, David R. (author)
- Wellcome Trust Sanger Institute
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- Martin, Sancha (author)
- Wellcome Trust Sanger Institute
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- Marshall, John (author)
- Wellcome Trust Sanger Institute
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- Anderson, Elizabeth (author)
- Wellcome Trust Sanger Institute
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- Hardy, Claire (author)
- Wellcome Trust Sanger Institute
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- Barbashina, Violetta (author)
- Institute of Cancer Research London
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- Aparicio, Samuel A J R (author)
- British Columbia Cancer Agency
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- Sauer, Torill (author)
- Oslo university hospital
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- Garred, Øystein (author)
- Oslo university hospital
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- Vincent-Salomon, Anne (author)
- Curie Institute, Paris
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- Mariani, Odette (author)
- Curie Institute, Paris
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- Boyault, Sandrine (author)
- Centre Léon Bérard
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- Fatima, Aquila (author)
- Dana-Farber Cancer Institute
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- Langerød, Anita (author)
- University of Oslo
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Thomas, Gilles (author)
- Centre Léon Bérard
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- Richardson, Andrea L. (author)
- Dana-Farber Cancer Institute
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- Børresen-Dale, Anne Lise (author)
- University of Oslo,Oslo university hospital
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- Polyak, Kornelia (author)
- Dana-Farber Cancer Institute
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- Stratton, Michael R. (author)
- Wellcome Trust Sanger Institute
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- Campbell, Peter J. (author)
- Addenbrooke's Hospital,University of Cambridge,Wellcome Trust Sanger Institute
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English 15 s.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 16:7, s. 2032-2046
- Related links:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://doi.org/10.1...
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Abstract
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- Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pipeline for analyzing RNA sequencing data, which we integrated with whole genomes from 23 breast cancers. Using X-inactivation analyses, we found that cancer cells are more transcriptionally active than intermixed stromal cells. This is especially true in estrogen receptor (ER)-negative tumors. Overall, 59% of substitutions were expressed. Nonsense mutations showed lower expression levels than expected, with patterns characteristic of nonsense-mediated decay. 14% of 4,234 rearrangements caused transcriptional abnormalities, including exon skips, exon reusage, fusions, and premature polyadenylation. We found productive, stable transcription from sense-to-antisense gene fusions and gene-to-intergenic rearrangements, suggesting that these mutation classes drive more transcriptional disruption than previously suspected. Systematic integration of transcriptome with genome data reveals the rules by which transcriptional machinery interprets somatic mutation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Shlien, Adam
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Raine, Keiran
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Fuligni, Fabio
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Arnold, Roland
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Nik-Zainal, Sere ...
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Dronov, Serge
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show more...
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Mamanova, Lira
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Rosic, Andrej
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Ju, Young Seok
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Cooke, Susanna L ...
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Ramakrishna, Man ...
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Papaemmanuil, El ...
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Davies, Helen R.
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Tarpey, Patrick ...
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Van Loo, Peter
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Wedge, David C.
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Jones, David R.
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Martin, Sancha
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Marshall, John
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Anderson, Elizab ...
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Hardy, Claire
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Barbashina, Viol ...
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Aparicio, Samuel ...
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Sauer, Torill
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Garred, Øystein
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Vincent-Salomon, ...
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Mariani, Odette
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Boyault, Sandrin ...
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Fatima, Aquila
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Langerød, Anita
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Borg, Åke
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Thomas, Gilles
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Richardson, Andr ...
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Børresen-Dale, A ...
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Polyak, Kornelia
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Stratton, Michae ...
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Campbell, Peter ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cell Reports
- By the university
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Lund University