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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005459naa a2200733 4500
001oai:lup.lub.lu.se:79f2cada-6cc2-4680-85c7-d0f995e56dc1
003SwePub
008161229s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/79f2cada-6cc2-4680-85c7-d0f995e56dc12 URI
0247 a https://doi.org/10.1016/j.celrep.2016.07.0282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Shlien, Adamu Wellcome Trust Sanger Institute4 aut
2451 0a Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
264 1b Elsevier BV,c 2016
300 a 15 s.
520 a Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pipeline for analyzing RNA sequencing data, which we integrated with whole genomes from 23 breast cancers. Using X-inactivation analyses, we found that cancer cells are more transcriptionally active than intermixed stromal cells. This is especially true in estrogen receptor (ER)-negative tumors. Overall, 59% of substitutions were expressed. Nonsense mutations showed lower expression levels than expected, with patterns characteristic of nonsense-mediated decay. 14% of 4,234 rearrangements caused transcriptional abnormalities, including exon skips, exon reusage, fusions, and premature polyadenylation. We found productive, stable transcription from sense-to-antisense gene fusions and gene-to-intergenic rearrangements, suggesting that these mutation classes drive more transcriptional disruption than previously suspected. Systematic integration of transcriptome with genome data reveals the rules by which transcriptional machinery interprets somatic mutation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Raine, Keiranu Wellcome Trust Sanger Institute4 aut
7001 a Fuligni, Fabiou Hospital for Sick Children, Toronto4 aut
7001 a Arnold, Rolandu Hospital for Sick Children, Toronto4 aut
7001 a Nik-Zainal, Serenau Wellcome Trust Sanger Institute4 aut
7001 a Dronov, Sergeu Wellcome Trust Sanger Institute4 aut
7001 a Mamanova, Lirau Wellcome Trust Sanger Institute4 aut
7001 a Rosic, Andreju Hospital for Sick Children, Toronto4 aut
7001 a Ju, Young Seoku Wellcome Trust Sanger Institute4 aut
7001 a Cooke, Susanna L.u Wellcome Trust Sanger Institute4 aut
7001 a Ramakrishna, Manasau Wellcome Trust Sanger Institute4 aut
7001 a Papaemmanuil, Elliu Wellcome Trust Sanger Institute4 aut
7001 a Davies, Helen R.u Wellcome Trust Sanger Institute4 aut
7001 a Tarpey, Patrick S.u Wellcome Trust Sanger Institute4 aut
7001 a Van Loo, Peteru Catholic University of Leuven,Wellcome Trust Sanger Institute4 aut
7001 a Wedge, David C.u Wellcome Trust Sanger Institute4 aut
7001 a Jones, David R.u Wellcome Trust Sanger Institute4 aut
7001 a Martin, Sanchau Wellcome Trust Sanger Institute4 aut
7001 a Marshall, Johnu Wellcome Trust Sanger Institute4 aut
7001 a Anderson, Elizabethu Wellcome Trust Sanger Institute4 aut
7001 a Hardy, Claireu Wellcome Trust Sanger Institute4 aut
7001 a Barbashina, Violettau Institute of Cancer Research London4 aut
7001 a Aparicio, Samuel A J Ru British Columbia Cancer Agency4 aut
7001 a Sauer, Torillu Oslo university hospital4 aut
7001 a Garred, Øysteinu Oslo university hospital4 aut
7001 a Vincent-Salomon, Anneu Curie Institute, Paris4 aut
7001 a Mariani, Odetteu Curie Institute, Paris4 aut
7001 a Boyault, Sandrineu Centre Léon Bérard4 aut
7001 a Fatima, Aquilau Dana-Farber Cancer Institute4 aut
7001 a Langerød, Anitau University of Oslo4 aut
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Thomas, Gillesu Centre Léon Bérard4 aut
7001 a Richardson, Andrea L.u Dana-Farber Cancer Institute4 aut
7001 a Børresen-Dale, Anne Liseu University of Oslo,Oslo university hospital4 aut
7001 a Polyak, Korneliau Dana-Farber Cancer Institute4 aut
7001 a Stratton, Michael R.u Wellcome Trust Sanger Institute4 aut
7001 a Campbell, Peter J.u Addenbrooke's Hospital,University of Cambridge,Wellcome Trust Sanger Institute4 aut
7102 a Wellcome Trust Sanger Instituteb Hospital for Sick Children, Toronto4 org
7730 t Cell Reportsd : Elsevier BVg 16:7, s. 2032-2046q 16:7<2032-2046x 2211-1247
8564 u http://dx.doi.org/10.1016/j.celrep.2016.07.028x freey FULLTEXT
8564 u http://www.cell.com/article/S2211124716309469/pdf
8564 8u https://lup.lub.lu.se/record/79f2cada-6cc2-4680-85c7-d0f995e56dc1
8564 8u https://doi.org/10.1016/j.celrep.2016.07.028

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