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Inhibition of aquap...
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways
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- Chen, Jiawei (författare)
- Wenzhou Medical University
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- Zhu, Xiandong (författare)
- The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
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- Wang, Ziqiong (författare)
- Wenzhou Medical University
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- Rützler, Michael (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Apoglyx AB
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- Lu, Qiaohong (författare)
- Wenzhou Medical University
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- Xu, Hongjie (författare)
- Wenzhou Medical University
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- Andersson, Roland (författare)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Dai, Yinwei (författare)
- Wenzhou Medical University
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- Shen, Zouwen (författare)
- Wenzhou Medical University
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- Calamita, Giuseppe (författare)
- University of Bari Aldo Moro
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- Xie, Shangjing (författare)
- Wenzhou Medical University
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- Bai, Yongheng (författare)
- Wenzhou Medical University
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- Chen, Bicheng (författare)
- Wenzhou Medical University
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: International Immunopharmacology. - 1567-5769. ; 137
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Inflammation, apoptosis and oxidative stress play crucial roles in the deterioration of severe acute pancreatitis-associated acute respiratory distress syndrome (SAP-ARDS). Unfortunately, despite a high mortality rate of 45 %[1], there are limited treatment options available for ARDS outside of last resort options such as mechanical ventilation and extracorporeal support strategies[2]. This study investigated the potential therapeutic role and mechanisms of AQP9 inhibitor RG100204 in two animal models of severe acute pancreatitis, inducing acute respiratory distress syndrome: 1) a sodium-taurocholate induced rat model, and 2) and Cerulein and lipopolysaccharide induced mouse model. RG100204 treatment led to a profound reduction in inflammatory cytokine expression in pancreatic, and lung tissue, in both models. In addition, infiltration of CD68 + and CD11b + cells into these tissues were reduced in RG100204 treated SAP animals, and edema and SAP associated tissue damage were improved. Moreover, we demonstrate that RG100204 reduced apoptosis in the lungs of rat SAP animals, and reduces NF-κB signaling, NLRP3, expression, while profoundly increasing the Nrf2-dependent anti oxidative stress response. We conclude that AQP9 inhibition is a promising strategy for the treatment of pancreatitis and its systemic complications, such as ARDS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Acute pancreatitis;AQP9, ARDS
- Nrf2
- Oxidative stress
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- art (ämneskategori)
- ref (ämneskategori)
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Chen, Jiawei
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Zhu, Xiandong
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Wang, Ziqiong
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Rützler, Michael
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Lu, Qiaohong
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Xu, Hongjie
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Andersson, Rolan ...
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Dai, Yinwei
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Shen, Zouwen
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Calamita, Giusep ...
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Xie, Shangjing
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Bai, Yongheng
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Chen, Bicheng
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