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WFRF:(Raijmakers Pieter G)
 

Sökning: WFRF:(Raijmakers Pieter G) > Carotid artery inti...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003778naa a2200493 4500
001oai:DiVA.org:uu-174731
003SwePub
008120525s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1747312 URI
0247 a https://doi.org/10.1093/ehjci/jes0382 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Danad, Ibrahim4 aut
2451 0a Carotid artery intima-media thickness, but not coronary artery calcium, predicts coronary vascular resistance in patients evaluated for coronary artery disease
264 c 2012-02-28
264 1b Oxford University Press (OUP),c 2012
338 a print2 rdacarrier
520 a Aims There is growing evidence that coronary artery disease (CAD) affects not only the conduit epicardial coronary arteries, but also the microvascular coronary bed. Moreover, coronary microvascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR). Methods and results We evaluated 120 patients (mean age 56 +/- 9 years, 58 men) without a documented history of CAD in whom and results obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress O-15-water positron emission tomography (PET)/CT, during which the coronary flow reserve (CFR) and minimal CVR were analysed. Minimal CVR increased significantly with increasing tertiles of C-IMT (22 +/- 6, 27 +/- 11, and 28 +/- 9 mmHg mL(-1) min(-1) g(-1), P < 0.01), whereas the CFR was comparable across all C-IMT groups (P = 0.50). Minimal CVR increased significantly with an increase in CAC score (23 +/- 9, 27 +/- 8, 32 +/- 10, and 32 +/- 7 mmHg mL(-1) min(-1) g(-1). P < 0.01), whereas the CFR did not show a significant decrease with higher CAC scores (P = 0.18). Multivariable regression analysis revealed that C-IMT (P = 0.03), but not CAC, was independently associated with minimal CVR. Conclusion C-IMT, but not CAC score, independently predicts minimal CVR in patients with multiple cardiovascular risk factors and suspected of CAD.
653 a C-IMT
653 a CAC score
653 a Coronary vascular resistance
653 a Coronary flow reserve
653 a O-15-water PET/CT
7001 a Raijmakers, Pieter G.4 aut
7001 a Kamali, Parisa4 aut
7001 a Harms, Hendrik J.4 aut
7001 a de Haan, Stefan4 aut
7001 a Lubberink, Marku Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)marklubb
7001 a van Kuijk, Cornelis4 aut
7001 a Hoekstra, Otto S.4 aut
7001 a Lammertsma, Adriaan A.4 aut
7001 a Smulders, Yvo M.4 aut
7001 a Heymans, Martijn W.4 aut
7001 a Tulevski, Igor I.4 aut
7001 a van Rossum, Albert C.4 aut
7001 a Knaapen, Paul4 aut
7102 a Uppsala universitetb Enheten för nuklearmedicin och PET4 org
7730 t European Heart Journal: Cardiovascular Imagingd : Oxford University Press (OUP)g 13:4, s. 317-323q 13:4<317-323x 2047-2404x 2047-2412
8564 u https://academic.oup.com/ehjcimaging/article-pdf/13/4/317/7118231/jes038.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174731
8564 8u https://doi.org/10.1093/ehjci/jes038

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