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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006434naa a2200625 4500
001oai:DiVA.org:umu-179981
003SwePub
008210216s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-88032
009oai:prod.swepub.kib.ki.se:145356640
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1799812 URI
0247 a https://doi.org/10.1007/s12028-020-01151-72 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-880322 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1453566402 URI
040 a (SwePub)umud (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Böhm, Julia K.u Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut
2451 0a Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) :b A CENTER-TBI Analysis
264 c 2020-12-11
264 1b Encyclopedia of Global Archaeology/Springer Verlag,c 2020
338 a electronic2 rdacarrier
520 a Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.Methods: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis.Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly.Conclusion: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a CENTER-TBI
653 a Traumatic brain injury
653 a Coagulopathy
653 a Risk factors
7001 a Güting, Helgeu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut
7001 a Thorn, Sophieu Emergency and Trauma Centre, Alfred Health, Melbourne, Australia4 aut
7001 a Schäfer, Nadineu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut
7001 a Rambach, Victoriau Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut
7001 a Schöchl, Herbertu Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria4 aut
7001 a Grottke, Oliveru Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany4 aut
7001 a Rossaint, Rolfu Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany4 aut
7001 a Stanworth, Simonu NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK4 aut
7001 a Curry, Nicolau NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK4 aut
7001 a Lefering, Rolfu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut
7001 a Maegele, Marcu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany; MaeDepartment of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Cologne, Germany4 aut
7001 a Vámos, Zoltán4 aut
7001 a Koskinen, Lars-Owe D.,c Professor,d 1955-u Umeå universitet,Neurovetenskaper4 ctb0 (Swepub:umu)lako0002
7001 a Brorsson, Camillau Umeå universitet,Anestesiologi och intensivvård0 (Swepub:umu)brca0001
7001 a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper0 (Swepub:oru)moc
7102 a Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germanyb Emergency and Trauma Centre, Alfred Health, Melbourne, Australia4 org
7730 t Neurocritical Cared : Encyclopedia of Global Archaeology/Springer Verlagg 35:1, s. 184-196q 35:1<184-196x 1541-6933x 1556-0961
8564 u https://doi.org/10.1007/s12028-020-01151-7y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1528691/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s12028-020-01151-7.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179981
8564 8u https://doi.org/10.1007/s12028-020-01151-7
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88032
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145356640

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