FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

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Fältnamn	Indikatorer	Metadata
000		09264naa a2201657 4500
001		oai:DiVA.org:umu-95221
003		SwePub
008		141024s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:46b63485-4e48-43f0-9e01-b51126e6a655
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-952212 URI
024	7	a https://doi.org/10.1093/hmg/ddu4112 DOI
024	7	a https://lup.lub.lu.se/record/46152562 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Qi, Qibinu Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USA4 aut
245	1 0	a FTO genetic variants, dietary intake and body mass index :b insights from 177 330 individuals
264		c 2014-08-07
264	1	b Oxford University Press (OUP),c 2014
338		a print2 rdacarrier
520		a FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Kilpeläinen, Tuomas O4 aut
700	1	a Kristiansson, Katiu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-kka
700	1	a Tanaka, Toshiko4 aut
700	1	a Smith, Caren E4 aut
700	1	a Sluijs, Ivonne4 aut
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
700	1	a Chu, Audrey Y4 aut
700	1	a Renström, Fridau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm
700	1	a Lin, Xiaochen4 aut
700	1	a Angquist, Lars H4 aut
700	1	a Huang, Jinyan4 aut
700	1	a Liu, Zhonghua4 aut
700	1	a Li, Yanping4 aut
700	1	a Asif Ali, Muhammad4 aut
700	1	a Xu, Min4 aut
700	1	a Ahluwalia, Tarunveer Singh4 aut
700	1	a Boer, Jolanda M A4 aut
700	1	a Chen, Peng4 aut
700	1	a Daimon, Makoto4 aut
700	1	a Eriksson, Johan4 aut
700	1	a Perola, Markusu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-mkp
700	1	a Friedlander, Yechiel4 aut
700	1	a Gao, Yu-Tang4 aut
700	1	a Heppe, Denise H M4 aut
700	1	a Holloway, John W4 aut
700	1	a Houston, Denise K4 aut
700	1	a Kanoni, Stavroula4 aut
700	1	a Kim, Yu-Mi4 aut
700	1	a Laaksonen, Maarit A4 aut
700	1	a Jääskeläinen, Tiina4 aut
700	1	a Lee, Nanette R4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Lemaitre, Rozenn N4 aut
700	1	a Lu, Wei4 aut
700	1	a Luben, Robert N4 aut
700	1	a Manichaikul, Ani4 aut
700	1	a Männistö, Satu4 aut
700	1	a Marques-Vidal, Pedro4 aut
700	1	a Monda, Keri L4 aut
700	1	a Ngwa, Julius S4 aut
700	1	a Perusse, Louis4 aut
700	1	a van Rooij, Frank J A4 aut
700	1	a Xiang, Yong-Bing4 aut
700	1	a Wen, Wanqing4 aut
700	1	a Wojczynski, Mary K4 aut
700	1	a Zhu, Jingwen4 aut
700	1	a Borecki, Ingrid B4 aut
700	1	a Bouchard, Claude4 aut
700	1	a Cai, Qiuyin4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Dedoussis, George V4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Forouhi, Nita G4 aut
700	1	a Hansen, Torben4 aut
700	1	a Christiansen, Lene4 aut
700	1	a Hofman, Albert4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003
700	1	a Jørgensen, Torben4 aut
700	1	a Karasawa, Shigeru4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kim, Mi-Kyung4 aut
700	1	a Kristiansson, Kati4 aut
700	1	a Li, Huaixing4 aut
700	1	a Lin, Xu4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Lohman, Kurt K4 aut
700	1	a Long, Jirong4 aut
700	1	a Mikkilä, Vera4 aut
700	1	a Mozaffarian, Dariush4 aut
700	1	a North, Kari4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Rissanen, Harri4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a van der Schouw, Yvonne T4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Carola Zillikens, M4 aut
700	1	a Franco, Oscar H4 aut
700	1	a Shyong Tai, E4 aut
700	1	a Ou Shu, Xiao4 aut
700	1	a Siscovick, David S4 aut
700	1	a Toft, Ulla4 aut
700	1	a Monique Verschuren, W M4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Witteman, Jacqueline C M4 aut
700	1	a Zheng, Wei4 aut
700	1	a Ridker, Paul M4 aut
700	1	a Kang, Jae H4 aut
700	1	a Liang, Liming4 aut
700	1	a Jensen, Majken K4 aut
700	1	a Curhan, Gary C4 aut
700	1	a Pasquale, Louis R4 aut
700	1	a Hunter, David J4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Uusitupa, Matti4 aut
700	1	a Adrienne Cupples, L4 aut
700	1	a Rankinen, Tuomo4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease4 aut0 (Swepub:lu)endo-mor
700	1	a Wang, Tao4 aut
700	1	a Chasman, Daniel I4 aut
700	1	a Franks, Paulu Lund University,Lunds universitet,Umeå universitet,Medicin,Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology4 aut0 (Swepub:lu)med-plf
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Hu, Frank B4 aut
700	1	a Loos, Ruth J F4 aut
700	1	a Nettleton, Jennifer A4 aut
700	1	a Qi, Lu4 aut
710	2	a Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USAb Genomik, diabetes och endokrinologi4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:25, s. 6961-6972q 23:25<6961-6972x 0964-6906x 1460-2083
856	4	u https://academic.oup.com/hmg/article-pdf/23/25/6961/13916787/ddu411.pdf
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/25104851?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1093/hmg/ddu411y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-95221
856	4 8	u https://doi.org/10.1093/hmg/ddu411
856	4 8	u https://lup.lub.lu.se/record/4615256

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Av författaren/redakt...: Qi, Qibin; Kilpeläinen, Tuo ...; Kristiansson, Ka ...; Tanaka, Toshiko; Smith, Caren E; Sluijs, Ivonne; visa fler...; Sonestedt, Emily; Chu, Audrey Y; Renström, Frida; Lin, Xiaochen; Angquist, Lars H; Huang, Jinyan; Liu, Zhonghua; Li, Yanping; Asif Ali, Muhamm ...; Xu, Min; Ahluwalia, Tarun ...; Boer, Jolanda M ...; Chen, Peng; Daimon, Makoto; Eriksson, Johan; Perola, Markus; Friedlander, Yec ...; Gao, Yu-Tang; Heppe, Denise H ...; Holloway, John W; Houston, Denise ...; Kanoni, Stavroul ...; Kim, Yu-Mi; Laaksonen, Maari ...; Jääskeläinen, Ti ...; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn ...; Lu, Wei; Luben, Robert N; Manichaikul, Ani; Männistö, Satu; Marques-Vidal, P ...; Monda, Keri L; Ngwa, Julius S; Perusse, Louis; van Rooij, Frank ...; Xiang, Yong-Bing; Wen, Wanqing; Wojczynski, Mary ...; Zhu, Jingwen; Borecki, Ingrid ...; Bouchard, Claude; Cai, Qiuyin; Cooper, Cyrus; Dedoussis, Georg ...; Deloukas, Panos; Ferrucci, Luigi; Forouhi, Nita G; Hansen, Torben; Christiansen, Le ...; Hofman, Albert; Johansson, Ingeg ...; Jørgensen, Torbe ...; Karasawa, Shiger ...; Khaw, Kay-Tee; Kim, Mi-Kyung; Li, Huaixing; Lin, Xu; Liu, Yongmei; Lohman, Kurt K; Long, Jirong; Mikkilä, Vera; Mozaffarian, Dar ...; North, Kari; Pedersen, Oluf; Raitakari, Olli; Rissanen, Harri; Tuomilehto, Jaak ...; van der Schouw, ...; Uitterlinden, An ...; Carola Zillikens ...; Franco, Oscar H; Shyong Tai, E; Ou Shu, Xiao; Siscovick, David ...; Toft, Ulla; Monique Verschur ...; Vollenweider, Pe ...; Wareham, Nichola ...; Witteman, Jacque ...; Zheng, Wei; Ridker, Paul M; Kang, Jae H; Liang, Liming; Jensen, Majken K; Curhan, Gary C; Pasquale, Louis ...; Hunter, David J; Mohlke, Karen L; Uusitupa, Matti; Adrienne Cupples ...; Rankinen, Tuomo; Orho-Melander, M ...; Wang, Tao; Chasman, Daniel ...; Franks, Paul; Sørensen, Thorki ...; Hu, Frank B; Loos, Ruth J F; Nettleton, Jenni ...; Qi, Lu; visa färre...

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