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Tropomyosin assembl...
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Grenklo, Staffan
(author)
Tropomyosin assembly intermediates in the control of MF-system turnover
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Elsevier BV,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-25021
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25021URI
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https://doi.org/10.1016/j.ejcb.2008.06.006DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117823225URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Tropomyosin is a coiled-coil α-helical protein, which self-associates in a head-to-tail fashion along polymers of actin to produce thin filaments. Mammalian non-muscle cells express a large number of tropomyosin isoforms, which are differentially regulated during embryogenesis and associated with specialized actin microfilament ensembles in cells. The function of tropomyosin in specifying form and localization of these subcellular structures, and the precise mechanism(s) by which they carry out their functions, is unclear. This paper reports that, while the major fraction of non-muscle cell tropomyosin resides in actin thin filaments of the cytomatrix, the soluble part of the cytoplasm contains tropomyosins in the form of actin-free multimers, which are isoform specific and of high molecular weight (MWapp 180,000–250,000). Stimulation of motile cells with growth factors induces a rapid, actin polymerization-dependent outgrowth of lamellipodia and filopodia. Concomitantly, the levels of tropomyosin isoform-specific multimers decrease, suggesting their involvement in actin thin filament formation. Malignant tumor cells have drastically altered levels and composition of tropomyosin isoform-specific multimers as well as tropomyosin in the cytomatrix.
Subject headings and genre
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Actin
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Tropomyosin
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Tropomyosin multimers
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Lamellipodia
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Filopodia
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Tumorigenesis
Added entries (persons, corporate bodies, meetings, titles ...)
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Hillberg, LouiseStockholms universitet,Wenner-Grens institut
(author)
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Zhao Rathje, Li-SophieKarolinska Institutet,Stockholms universitet,Wenner-Grens institut(Swepub:su)lzhao
(author)
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Pinaev, George
(author)
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Schutt, Clarence E.
(author)
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Lindberg, UnoKarolinska Institutet
(author)
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Stockholms universitetWenner-Grens institut
(creator_code:org_t)
Related titles
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In:European Journal of Cell Biology: Elsevier BV87:11, s. 905-9200171-93351618-1298
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