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Identification of T...
Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection
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- Schuck, Sebastian D (author)
- Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
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- Mueller, Henrik (author)
- Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
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- Kunitz, Frank (author)
- Respiratory Diseases Clinic Heckeshorn, Department of Pneumology, HELIOS Klinikum Emil von Behring, Berlin, Germany
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- Neher, Albert (author)
- Asklepios Professional Clinic München-Gauting, Centre for Pneumology and Thorax Surgery, Munich, Germany
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- Hoffmann, Harald (author)
- Asklepios Professional Clinic München-Gauting, Centre for Pneumology and Thorax Surgery, Munich, Germany
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- Franken, Kees L C M (author)
- Department of Immunohematology & Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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- Repsilber, Dirk, 1971- (author)
- Research Institute for the Biology of Farm Animals, Genetics and Biometry, Dummerstorf, Germany
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- Ottenhoff, Tom H M (author)
- Department of Immunohematology & Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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- Kaufmann, Stefan H E (author)
- Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
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- Jacobsen, Marc (author)
- Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
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(creator_code:org_t)
- 2009-05-18
- 2009
- English.
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In: PLOS ONE. - San Fransisco, USA : Public Library Science. - 1932-6203. ; 4:5
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Abstract
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- Background: T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans.Methodology/Principal findings: We established an assay based on two rounds of in vitro restimulation and intracellular cytokine analysis that detects T-cell responses to antigens expressed during latent M. tuberculosis infection. Comparison between active pulmonary tuberculosis (TB) patients and healthy latently M. tuberculosis-infected donors (LTBI) revealed significantly higher T-cell responses against 7 of 35 tested M. tuberculosis latency-associated antigens in LTBI. Notably, T cells specific for Rv3407 were exclusively detected in LTBI but not in TB patients. The T-cell IFNgamma response against Rv3407 in individual donors was the most influential factor in discrimination analysis that classified TB patients and LTBI with 83% accuracy using cross-validation. Rv3407 peptide pool stimulations revealed distinct candidate epitopes in four LTBI.Conclusions: Our findings further support the hypothesis that the latency-associated antigens can be exploited as biomarkers for LTBI.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
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- art (subject category)
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Schuck, Sebastia ...
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Mueller, Henrik
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Kunitz, Frank
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Neher, Albert
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Hoffmann, Harald
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Franken, Kees L ...
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Repsilber, Dirk, ...
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Ottenhoff, Tom H ...
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Kaufmann, Stefan ...
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Jacobsen, Marc
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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PLOS ONE
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Örebro University