Sökning: WFRF:(Rizzello Giulia) >
Dupilumab for relap...
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis : a European retrospective study
-
- Molina, Berengere (författare)
- Hosp Cochin, Dept Internal Med, Paris, France.
-
- Padoan, Roberto (författare)
- Univ Padua, Dept Med DIMED, Div Rheumatol, Padua, Italy.
-
- Urban, Maria Letizia (författare)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy.
-
visa fler...
-
- Novikov, Pavel (författare)
- IM Sechenov First Moscow State Med Univ, Tareev Clin Internal Dis, Moscow, Russia.
-
- Caminati, Marco (författare)
- Univ Verona, Dept Med Asthma Allergy & Clin Immunol, Verona, Italy.
-
- Taillé, Camille (författare)
- Nord Univ Paris Cite, Bichat Hosp, Dept Resp Dis, APHP, Paris, France.
-
- Néel, Antoine (författare)
- Nantes Univ Hosp, Dept Internal Med, Nantes, France.
-
- Bouillet, Laurence (författare)
- Grenoble Alpes Univ Hosp, T Reg Unit, CNRS, UMR 5525,5,VetAgro Sup, Grenoble, France.;Grenoble Univ Hosp, Internal Med Dept, Grenoble, France.
-
- Fraticelli, Paolo (författare)
- Univ Hosp Osped Riuniti, Internal Med Dept, Ancona, Italy.
-
- Schleinitz, Nicolas (författare)
- Aix Marseille Univ, Timone Hosp AP HM, Dept Internal Med, Marseille, France.
-
- Christides, Christine (författare)
- Avignon Hosp, Dept Internal Med, Avignon, France.
-
- Moi, Laura (författare)
- Valais Hosp, Inst Cent Hop, Immunol & Allergol, Sion, Switzerland.
-
- Godeau, Bertrand (författare)
- Henri Mondor Univ Hosp, Dept Internal Med, Creteil, France.
-
- Knight, Ann (författare)
- Uppsala universitet,Reumatologi
-
- Schroeder, Jan Walter (författare)
- ASST Grande Osped Metropolitano Niguarda, Unit Allergol & Immunol, Milan, Italy.
-
- Marchand-Adam, Sylvain (författare)
- Reg Univ Hosp Ctr, Dept Resp Med, Tours, France.
-
- Gil, Helder (författare)
- Besancon Univ Hosp, Dept Internal Med, Besancon, France.
-
- Cottin, Vincent (författare)
- Louis Pradel Hosp, Coordinating Reference Ctr Rare Pulm Dis, Dept Resp Med, Bron, France.
-
- Durel, Cécile-Audrey (författare)
- Univ Hosp Edouard Herriot, Dept Internal Med, HCL, Lyon, France.
-
- Gelain, Elena (författare)
- Meyer Childrens Hosp, Nephrol & Dialysis Unit, Florence, Italy.
-
- Lerais, Boris (författare)
- Brest Univ Hosp, Dept Internal Med, Brest, France.
-
- Ruivard, Marc (författare)
- Univ Hosp Ctr, Internal Med, Clermont Ferrand, France.
-
- Groh, Matthieu (författare)
- Foch Hosp, Natl Referral Ctr Hypereosinophil Syndrome CEREO, Dept Internal Med, Suresnes, France.
-
- Samson, Maxime (författare)
- Univ Hosp Ctr, Dept Internal Med & Clin Immunol, Dijon, France.;Univ Bourgogne Franche Comte, INSERM, EFS BFC, UMR1098,RIGHT Interact Greffon Hote Tumeur Ingenie, Dijon, France.
-
- Moroni, Luca (författare)
- Ist Sci San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis UnIRAR, Milan, Italy.
-
- Thiel, Jens (författare)
- Univ Freiburg, Med Ctr, Dept Rheumatol & Clin Immunol, Freiburg, Germany.;Med Univ, Dept Internal Med, Div Rheumatol & Clin Immunol, Graz, Austria.
-
- Kernder, Anna (författare)
- Heinrich Heine Univ Dusseldorf, Med Fac, Dept Rheumatol & Hiller Res Unit Rheumatol, Dusseldorf, Germany.
-
- Cohen Tervaert, Jan Willem (författare)
- Univ Alberta, Dept Med, Edmonton, AB, Canada.;Maastricht Univ, Sch Mental Hlth & Neurosci, Maastricht, Netherlands.
-
- Costanzo, Giulia (författare)
- Univ Cagliari, Dept Med Sci & Publ Hlth, Monserrato, Italy.
-
- Folci, Marco (författare)
- Fdn Poliambulanza Ist Osped, Brescia, Italy.
-
- Rizzello, Sonia (författare)
- Careggi Univ Hosp, Severe Asthma Unit, Florence, Italy.
-
- Cohen, Pascal (författare)
- Cochin Hosp, Dept Internal Med, Paris, France.
-
- Emmi, Giacomo (författare)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy.;Monash Univ, Ctr Inflammatory Dis, Monash Med Ctr, Dept Med, Clayton, Vic, Australia.
-
- Terrier, Benjamin (författare)
- Hosp Cochin, Dept Internal Med, F-75014 Paris, Ile De France, France.;Hosp Cochin, Dept Internal Med, Paris, France.
-
visa färre...
-
Hosp Cochin, Dept Internal Med, Paris, France Univ Padua, Dept Med DIMED, Div Rheumatol, Padua, Italy. (creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- Engelska.
-
Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 82:12, s. 1587-1593
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated with glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations. When immunosuppressants and/or mepolizumab are ineffective, dupilumab could be an option. We describe the safety and efficacy of off-label use of dupilumab in relapsing and/or refractory EGPA.Patients and methods We conducted an observational multicentre study of EGPA patients treated with dupilumab. Complete response was defined by Birmingham Vasculitis Activity Score (BVAS)=0 and prednisone dose ≤4 mg/day, and partial response by BVAS=0 and prednisone dose >4 mg/day. Eosinophilia was defined as an eosinophil count >500/mm3.Results Fifty-one patients were included. The primary indication for dupilumab was disabling ENT symptoms in 92%. After a median follow-up of 13.1 months, 18 patients (35%) reported adverse events (AEs), including two serious AEs. Eosinophilia was reported in 34 patients (67%), with a peak of 2195/mm3 (IQR 1268–4501) occurring at 13 weeks (IQR 4–36) and was associated with relapse in 41%. Twenty-one patients (41%) achieved a complete response and 12 (24%) a partial response. Sixteen (31%) patients experienced an EGPA relapse while on dupilumab, which was associated with blood eosinophilia in 14/16 (88%) patients. The median eosinophil count at the start of dupilumab was significantly lower in relapsers than in non-relapsers, as was the median time between stopping anti-IL-5/IL-5R and switching to dupilumab.Conclusion These results suggest that dupilumab may be effective in treating patients with EGPA-related ENT manifestations. However, EGPA flares occurred in one-third of patients and were preceded by eosinophilia in 88%, suggesting that caution is required.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Systemic vasculitis
- Immune System Diseases
- Biological Therapy
- Autoimmune Diseases
- Therapeutics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Molina, Berenger ...
-
Padoan, Roberto
-
Urban, Maria Let ...
-
Novikov, Pavel
-
Caminati, Marco
-
Taillé, Camille
-
visa fler...
-
Néel, Antoine
-
Bouillet, Lauren ...
-
Fraticelli, Paol ...
-
Schleinitz, Nico ...
-
Christides, Chri ...
-
Moi, Laura
-
Godeau, Bertrand
-
Knight, Ann
-
Schroeder, Jan W ...
-
Marchand-Adam, S ...
-
Gil, Helder
-
Cottin, Vincent
-
Durel, Cécile-Au ...
-
Gelain, Elena
-
Lerais, Boris
-
Ruivard, Marc
-
Groh, Matthieu
-
Samson, Maxime
-
Moroni, Luca
-
Thiel, Jens
-
Kernder, Anna
-
Cohen Tervaert, ...
-
Costanzo, Giulia
-
Folci, Marco
-
Rizzello, Sonia
-
Cohen, Pascal
-
Emmi, Giacomo
-
Terrier, Benjami ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Annals of the Rh ...
- Av lärosätet
-
Uppsala universitet