Sökning: WFRF:(Rydell Mina) > (2016) > Association of Peri...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05945naa a2200505 4500 | |
001 | oai:DiVA.org:oru-52876 | |
003 | SwePub | |
008 | 161010s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134589675 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-528762 URI |
024 | 7 | a https://doi.org/10.1001/jamapsychiatry.2016.20952 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1345896752 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Brander, Gustafu Karolinska Institutet4 aut |
245 | 1 0 | a Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder :b A Population-Based Birth Cohort, Sibling Control Study |
264 | 1 | a Chicago, USA :b American Medical Association,c 2016 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Karolinska InstitutetSwedish Research Council for Health, Working Life, and Welfare 2015-00075 2015-00569David and Astrid Hagelen Foundation | |
520 | a Importance: Perinatal complications may increase the risk of obsessive-compulsive disorder (OCD). Previous reports were based on small, retrospective, specialist clinic-based studies that were unable to rigorously control for unmeasured environmental and genetic confounding.Objective: To prospectively investigate a wide range of potential perinatal risk factors for OCD, controlling for unmeasured factors shared between siblings in the analyses.Design, Setting, and Participants: This population-based birth cohort study included all 2 421 284 children from singleton births in Sweden from January 1, 1973, to December 31, 1996, who were followed up through December 31, 2013. From the 1 403 651 families in the cohort, differentially exposed siblings from the 743 885 families with siblings were evaluated; of these, 11 592 families included clusters of full siblings that were discordant for OCD. Analysis of the data was conducted from January, 26, 2015, to September, 5, 2016.Exposures: Perinatal data were collected from the Swedish Medical Birth Register and included maternal smoking during pregnancy, labor presentation, obstetric delivery, gestational age (for preterm birth), birth weight, birth weight in relation to gestational age, 5-minute Apgar score, and head circumference.Main Outcomes and Measures: Previously validated OCD codes (International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, code F42) in the Swedish National Patient Register.Results: Of 2 421 284 individuals included in the cohort, 17 305 persons were diagnosed with OCD. Of these, 7111 were men (41.1%). The mean (SD) age of individuals at first diagnosis of OCD was 23.4 (6.5) years. An increased risk for OCD remained after controlling for shared familial confounders and measured covariates (including sex, year of birth, maternal and paternal age at birth, and parity), for smoking 10 or more cigarettes per day during pregnancy (hazard ratio [HR], 1.27; 95% CI, 1.02-1.58), breech presentation (HR, 1.35; 95% CI, 1.06-1.71), delivery by cesarean section (HR, 1.17; 95% CI, 1.01-1.34), preterm birth (HR, 1.24; 95% CI, 1.07-1.43), birth weight 1501 to 2500 g (HR, 1.30; 95% CI, 1.05-1.62) and 2501 to 3500 g (HR, 1.08; 95% CI, 1.01-1.16), being large for gestational age (HR, 1.23; 95% CI, 1.05-1.45), and Apgar distress scores at 5 minutes (HR, 1.50; 95% CI, 1.07-2.09). Gestational age and birth weight followed inverse dose-response associations, whereby an increasingly higher risk for OCD was noted in children with a shorter gestational age and lower birth weight. We also observed a dose-response association between the number of perinatal events and increased OCD risk, with HRs ranging from 1.11 (95% CI, 1.07-1.15) for 1 event to 1.51 (95% CI, 1.18-1.94) for 5 or more events.Conclusions and Relevance: A range of perinatal risk factors is associated with a higher risk for OCD independent of shared familial confounders, suggesting that perinatal risk factors may be in the causal pathway to OCD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
653 | a Psychiatry | |
653 | a Psykiatri | |
700 | 1 | a Rydell, Minau Karolinska Institutet4 aut |
700 | 1 | a Kuja-Halkola, Ralfu Karolinska Institutet4 aut |
700 | 1 | a Fernández de la Cruz, Lorenau Karolinska Institutet4 aut |
700 | 1 | a Lichtenstein, Paulu Karolinska Institutet4 aut |
700 | 1 | a Serlachius, Evau Karolinska Institutet4 aut |
700 | 1 | a Rück, Christianu Karolinska Institutet4 aut |
700 | 1 | a Almqvist, Catarinau Karolinska Institutet4 aut |
700 | 1 | a D'Onofrio, Brian M.u Karolinska Institutet4 aut |
700 | 1 | a Larsson, Henrik,d 1975-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln |
700 | 1 | a Mataix-Cols, Davidu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t JAMA psychiatryd Chicago, USA : American Medical Associationg 73:11, s. 1135-1144q 73:11<1135-1144x 2168-6238x 2168-622X |
856 | 4 | u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2565603/yoi160058.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-52876 |
856 | 4 8 | u https://doi.org/10.1001/jamapsychiatry.2016.2095 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134589675 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy