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Reproductive risk f...
Reproductive risk factors and endometrial cancer : the European prospective investigation into cancer and nutrition
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Dossus, Laure (author)
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Allen, Naomi (author)
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Kaaks, Rudolf (author)
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show more...
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Bakken, Kjersti (author)
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Lund, Eiliv (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Clavel-Chapelon, Francoise (author)
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Fournier, Agnes (author)
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Chabbert-Buffet, Nathalie (author)
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Boeing, Heiner (author)
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Schütze, Madlen (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Lagiou, Pagona (author)
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Palli, Domenico (author)
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Krogh, Vittorio (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Mattiello, Amalia (author)
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Bueno-de-Mesquita, H Bas (author)
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Onland-Moret, N Charlotte (author)
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Peeters, Petra H M (author)
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Dumeaux, Vanessa (author)
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Redondo, Maria-Luisa (author)
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Duell, Eric (author)
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Sanchez-Cantalejo, Emilio (author)
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Arriola, Larraitz (author)
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Chirlaque, Maria-Dolores (author)
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Ardanaz, Eva (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Lukanova, Annie (author)
- Umeå universitet,Näringsforskning
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Khaw, Kay-Tee (author)
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Wareham, Nicholas (author)
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Key, Tim (author)
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Chajes, Veronique (author)
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Rinaldi, Sabina (author)
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Slimani, Nadia (author)
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Mouw, Traci (author)
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Gallo, Valentina (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 127:2, s. 442-451
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- endometrial cancer;parity;menarche;menopause;oral contraceptive
- Oncology
- Onkologi
- Pathology
- patologi
- menopause
- menarche
- endometrial cancer
- parity
- oral contraceptive
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Dossus, Laure
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Allen, Naomi
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Kaaks, Rudolf
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Bakken, Kjersti
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Lund, Eiliv
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Tjonneland, Anne
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show more...
-
Olsen, Anja
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Overvad, Kim
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Clavel-Chapelon, ...
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Fournier, Agnes
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Chabbert-Buffet, ...
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Boeing, Heiner
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Schütze, Madlen
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Lagiou, Pagona
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Bueno-de-Mesquit ...
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Onland-Moret, N ...
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Peeters, Petra H ...
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Dumeaux, Vanessa
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Redondo, Maria-L ...
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Duell, Eric
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Sanchez-Cantalej ...
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Arriola, Larrait ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Manjer, Jonas
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Borgquist, Signe
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Lukanova, Annie
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Lundin, Eva
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Key, Tim
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Chajes, Veroniqu ...
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Rinaldi, Sabina
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Slimani, Nadia
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Mouw, Traci
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Gallo, Valentina
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Riboli, Elio
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University