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Deletions on Chromo...
Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients
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- Lysiak, Malgorzata (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Smits, Anja (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Landtblom: Neurovetenskap,Department of Neuroscience and Physiology, Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg,Univ Gothenburg, Sweden; Uppsala Univ, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Roodakker, Kenney Roy, 1989- (author)
- Uppsala universitet,Landtblom: Neurovetenskap,Uppsala Univ, Sweden
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- Sandberg, Elisabeth (author)
- Uppsala universitet,Landtblom: Neurovetenskap,Uppsala Univ, Sweden
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- Dimberg, Anna (author)
- Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Sweden
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- Mudaisi, Munila (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Bratthäll, Charlotte (author)
- Dist Hosp, Sweden
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- Strandeus, Michael (author)
- Ryhov Hosp, Sweden
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- Milos, Peter (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US
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- Hallbeck, Martin (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi
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- Söderkvist, Peter (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Malmström, Annika (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Närvårdskliniken
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(creator_code:org_t)
- 2021-03-31
- 2021
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 13:7
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- BACKGROUND: Biological causes of sex disparity seen in the prevalence of cancer, including glioblastoma (GBM), remain poorly understood. One of the considered aspects is the involvement of the sex chromosomes, especially loss of chromosome Y (LOY).METHODS: Tumors from 105 isocitrate dehydrogenase (IDH) wild type male GBM patients were tested with droplet digital PCR for copy number changes of ten genes on chromosome Y. Decreased gene expression, a proxy of gene loss, was then analyzed in 225 IDH wild type GBM derived from TCGA and overall survival in both cohorts was tested with Kaplan-Meier log-rank analysis and maximally selected rank statistics for cut-off determination.RESULTS: LOY was associated with significantly shorter overall survival (7 vs. 14.6 months, p = 0.0016), and among investigated individual genes survival correlated most prominently with loss of the sex-determining region Y gene (SRY) (10.8 vs. 14.8 months, p = 0.0031). Gene set enrichment analysis revealed that epidermal growth factor receptor, platelet-derived growth factor receptor, and MYC proto-oncogene signaling pathways are associated with low SRY expression.CONCLUSION: Our data show that deletions and reduced gene expression of chromosome Y genes, especially SRY, are associated with reduced survival of male GBM patients and connected to major susceptibility pathways of gliomagenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- LOY
- SRY
- Y chromosome
- glioblastoma
- sex bias
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Lysiak, Malgorza ...
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Smits, Anja
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Roodakker, Kenne ...
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Sandberg, Elisab ...
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Dimberg, Anna
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Mudaisi, Munila
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Bratthäll, Charl ...
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Strandeus, Micha ...
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Milos, Peter
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Hallbeck, Martin
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Söderkvist, Pete ...
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Malmström, Annik ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancers
- By the university
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Uppsala University
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Linköping University
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University of Gothenburg