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Sökning: WFRF:(Sanchez Alavez Manuel) > (2019) > Activation of Kappa...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003233naa a2200433 4500
001oai:DiVA.org:su-177439
003SwePub
008200121s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1774392 URI
0247 a https://doi.org/10.1016/j.cub.2019.10.0272 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cintron-Colon, Rigo4 aut
2451 0a Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss
264 1b Elsevier BV,c 2019
338 a print2 rdacarrier
520 a Mammals maintain a nearly constant core body temperature (T-b) by balancing heat production and heat dissipation. This comes at a high metabolic cost that is sustainable if adequate calorie intake is maintained. When nutrients are scarce or experimentally reduced such as during calorie restriction (CR), endotherms can reduce energy expenditure by lowering T-b [1-6]. This adaptive response conserves energy, limiting the loss of body weight due to low calorie intake [710]. Here we show that this response is regulated by the kappa opioid receptor (KOR). CR is associated with increased hypothalamic levels of the endogenous opioid Leuenkephalin, which is derived from the KOR agonist precursor dynorphin [11]. Pharmacological inhibition of KOR, but not of the delta or the mu opioid receptor subtypes, fully blocked CR-induced hypothermia and increased weight loss during CR independent of calorie intake. Similar results were seen with DIO mice subjected to CR. In contrast, inhibiting KOR did not change T-b in animals fed ad libitum (AL). Chemogenetic inhibition of KOR neurons in the hypothalamic preoptic area reduced the CR-induced hypothermia, whereas chemogenetic activation of prodynorphin-expressing neurons in the arcuate or the parabrachial nucleus lowered T-b. These data indicate that KOR signaling is a pivotal regulator of energy homeostasis and can affect body weight during dieting by modulating T-b and energy expenditure.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
7001 a Johnson, Christopher W.4 aut
7001 a Montenegro-Burke, J. Rafael4 aut
7001 a Guijas, Carlos4 aut
7001 a Faulhaber, Lila4 aut
7001 a Sanchez-Alavez, Manuel4 aut
7001 a Aguirre, Carlos A.4 aut
7001 a Shankar, Kokila4 aut
7001 a Singh, Mona4 aut
7001 a Galmozzi, Andrea4 aut
7001 a Siuzdak, Gary4 aut
7001 a Saez, Enrique4 aut
7001 a Conti, Brunou Stockholms universitet,Institutionen för biokemi och biofysik,The Scripps Research Institute, USA4 aut
7102 a Stockholms universitetb Institutionen för biokemi och biofysik4 org
7730 t Current Biologyd : Elsevier BVg 29:24, s. 4291-4299q 29:24<4291-4299x 0960-9822x 1879-0445
8564 u http://www.cell.com/article/S0960982219313673/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-177439
8564 8u https://doi.org/10.1016/j.cub.2019.10.027

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