Sökning: WFRF:(Sandanger Torkjel) > (2023) > Blood cell DNA meth...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 08782naa a2200733 4500 | |
001 | oai:DiVA.org:umu-201243 | |
003 | SwePub | |
008 | 221205s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2012432 URI |
024 | 7 | a https://doi.org/10.1002/ijc.343392 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Allione, Alessandrau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
245 | 1 0 | a Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma :b the EPIC prospective cohort |
264 | c 2022-11-05 | |
264 | 1 | b John Wiley & Sons,c 2023 |
338 | a print2 rdacarrier | |
520 | a Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a cancer biomarkers | |
653 | a DNA methylation | |
653 | a mesothelioma | |
653 | a prospective nested case-control study | |
653 | a Oncology | |
653 | a onkologi | |
700 | 1 | a Viberti, Clarau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Cotellessa, Ilariau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Catalano, Chiarau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Casalone, Elisabettau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Cugliari, Giovanniu Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Russo, Alessiau Department of Medical Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Guarrera, Simonettau Candiolo Cancer Institute, FPO—IRCCS, Candiolo, Italy4 aut |
700 | 1 | a Mirabelli, Dariou Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy4 aut |
700 | 1 | a Sacerdote, Carlottau Unit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy4 aut |
700 | 1 | a Gentile, Marcou A.O.U. Federico II, Naples, Italy4 aut |
700 | 1 | a Eichelmann, Fabianu Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany4 aut |
700 | 1 | a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany4 aut |
700 | 1 | a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105 |
700 | 1 | a Eriksen, Anne Kirstineu Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark4 aut |
700 | 1 | a Tjønneland, Anneu Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Andersson, Martinu Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)manann00 |
700 | 1 | a Dollé, Martijn E.T.u Centre for Health Protection National Institute for Public Health and the Environment, Bilthoven, Netherlands4 aut |
700 | 1 | a Van Puyvelde, Heleenu International Agency for Research on Cancer, World Health Organisation, Lyon, France4 aut |
700 | 1 | a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organisation, Lyon, France4 aut |
700 | 1 | a Rodriguez-Barranco, Miguelu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut |
700 | 1 | a Agudo, Antoniou Unit of Nutrition and Cancer, Catalan Institute of Oncology—ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute—IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain4 aut |
700 | 1 | a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Chirlaque, María-Doloresu CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain4 aut |
700 | 1 | a Truong, Thérèseu Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France4 aut |
700 | 1 | a Dragic, Dzevkau Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Centre de Recherche sur le Cancer de l'Université Laval, Département de Médecine Sociale et Préventive, Faculté de Médecine, Québec, Canada; Axe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada4 aut |
700 | 1 | a Severi, Gianlucau Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Department of Statistics, Computer Science and Applications “G. Parenti” (DISIA), University of Florence, Florence, Italy4 aut |
700 | 1 | a Sieri, Sabinau Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy4 aut |
700 | 1 | a Sandanger, Torkjel M.u Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Ardanaz, Evau CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain4 aut |
700 | 1 | a Vineis, Paolou MRC Centre for Environment and Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Matullo, Giuseppeu Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy; Medical Genetics Unit, AOU Città della Salute e Della Scienza, Turin, Italy4 aut |
710 | 2 | a Department of Medical Sciences, University of Turin, Turin, Italyb Candiolo Cancer Institute, FPO—IRCCS, Candiolo, Italy4 org |
773 | 0 | t International Journal of Cancerd : John Wiley & Sonsg 152:4, s. 725-737q 152:4<725-737x 0020-7136x 1097-0215 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201243 |
856 | 4 8 | u https://doi.org/10.1002/ijc.34339 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.