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Sökning: WFRF:(Sandanger Torkjel) > (2023) > Blood cell DNA meth...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008782naa a2200733 4500
001oai:DiVA.org:umu-201243
003SwePub
008221205s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2012432 URI
0247 a https://doi.org/10.1002/ijc.343392 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Allione, Alessandrau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
2451 0a Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma :b the EPIC prospective cohort
264 c 2022-11-05
264 1b John Wiley & Sons,c 2023
338 a print2 rdacarrier
520 a Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a cancer biomarkers
653 a DNA methylation
653 a mesothelioma
653 a prospective nested case-control study
653 a Oncology
653 a onkologi
7001 a Viberti, Clarau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Cotellessa, Ilariau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Catalano, Chiarau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Casalone, Elisabettau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Cugliari, Giovanniu Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Russo, Alessiau Department of Medical Sciences, University of Turin, Turin, Italy4 aut
7001 a Guarrera, Simonettau Candiolo Cancer Institute, FPO—IRCCS, Candiolo, Italy4 aut
7001 a Mirabelli, Dariou Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy4 aut
7001 a Sacerdote, Carlottau Unit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy4 aut
7001 a Gentile, Marcou A.O.U. Federico II, Naples, Italy4 aut
7001 a Eichelmann, Fabianu Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany4 aut
7001 a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany4 aut
7001 a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
7001 a Eriksen, Anne Kirstineu Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Andersson, Martinu Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)manann00
7001 a Dollé, Martijn E.T.u Centre for Health Protection National Institute for Public Health and the Environment, Bilthoven, Netherlands4 aut
7001 a Van Puyvelde, Heleenu International Agency for Research on Cancer, World Health Organisation, Lyon, France4 aut
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organisation, Lyon, France4 aut
7001 a Rodriguez-Barranco, Miguelu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
7001 a Agudo, Antoniou Unit of Nutrition and Cancer, Catalan Institute of Oncology—ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute—IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain4 aut
7001 a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Chirlaque, María-Doloresu CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain4 aut
7001 a Truong, Thérèseu Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France4 aut
7001 a Dragic, Dzevkau Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Centre de Recherche sur le Cancer de l'Université Laval, Département de Médecine Sociale et Préventive, Faculté de Médecine, Québec, Canada; Axe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada4 aut
7001 a Severi, Gianlucau Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Department of Statistics, Computer Science and Applications “G. Parenti” (DISIA), University of Florence, Florence, Italy4 aut
7001 a Sieri, Sabinau Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy4 aut
7001 a Sandanger, Torkjel M.u Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Ardanaz, Evau CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain4 aut
7001 a Vineis, Paolou MRC Centre for Environment and Health, Imperial College London, London, United Kingdom4 aut
7001 a Matullo, Giuseppeu Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy; Medical Genetics Unit, AOU Città della Salute e Della Scienza, Turin, Italy4 aut
7102 a Department of Medical Sciences, University of Turin, Turin, Italyb Candiolo Cancer Institute, FPO—IRCCS, Candiolo, Italy4 org
7730 t International Journal of Cancerd : John Wiley & Sonsg 152:4, s. 725-737q 152:4<725-737x 0020-7136x 1097-0215
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201243
8564 8u https://doi.org/10.1002/ijc.34339

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