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Anthropometric and ...
Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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- Sanikini, Harinakshi (författare)
- Imperial College London
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- Muller, David C. (författare)
- Imperial College London
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- Sophiea, Marisa (författare)
- Imperial College London
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer, World Health Organization
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research,University of Helsinki
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- Overvad, Kim (författare)
- Aarhus University
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Halkjær, Jytte (författare)
- Danish Cancer Society
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- Boutron-Ruault, Marie Christine (författare)
- University of Paris-Saclay,Institut Gustave Roussy
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- Carbonnel, Franck (författare)
- Institut Gustave Roussy,Bicêtre Hospital,University of Paris-Saclay
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- Cervenka, Iris (författare)
- University of Paris-Saclay,Institut Gustave Roussy
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens
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- Martimianaki, Georgia (författare)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens,Attikon University Hospital
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- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Rylander, Charlotta (författare)
- UiT The Arctic University of Norway, Tromsø
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- Chirlaque López, María Dolores (författare)
- University of Murcia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Sánchez, Maria Jose (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Hospital Clínico Universitario San Cecilio,University of Granada
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP)
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- Regnér, Sara (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Stocks, Tanja (författare)
- Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Bueno-de-Mesquita, Bas (författare)
- University of Malaya,National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht,Imperial College London
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- Vermeulen, Roel C.H. (författare)
- Utrecht University,University Medical Center Utrecht
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- Aune, Dagfinn (författare)
- Imperial College London,Bjørknes University College,Oslo university hospital
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- Tong, Tammy Y.N. (författare)
- University of Oxford
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- Kliemann, Nathalie (författare)
- International Agency for Research on Cancer, World Health Organization
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, World Health Organization
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- Chadeau-Hyam, Marc (författare)
- Imperial College London
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Cross, Amanda J. (författare)
- Imperial College London
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(creator_code:org_t)
- 2019-05-21
- 2020
- Engelska 14 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:4, s. 929-942
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- cancer
- esophageal
- gastric
- hormones
- obesity
- reproductive
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Sanikini, Harina ...
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Muller, David C.
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Sophiea, Marisa
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Rinaldi, Sabina
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Agudo, Antonio
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Duell, Eric J.
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visa fler...
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Weiderpass, Elis ...
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Overvad, Kim
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Tjønneland, Anne
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Halkjær, Jytte
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Cervenka, Iris
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Boeing, Heiner
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Kaaks, Rudolf
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Kühn, Tilman
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Trichopoulou, An ...
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Martimianaki, Ge ...
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Karakatsani, Ann ...
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Pala, Valeria
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Palli, Domenico
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Mattiello, Amali ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Skeie, Guri
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Rylander, Charlo ...
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Chirlaque López, ...
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Sánchez, Maria J ...
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Ardanaz, Eva
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Regnér, Sara
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Stocks, Tanja
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Bueno-de-Mesquit ...
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Vermeulen, Roel ...
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Aune, Dagfinn
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Tong, Tammy Y.N.
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Kliemann, Nathal ...
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Murphy, Neil
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Chadeau-Hyam, Ma ...
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Gunter, Marc J.
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Cross, Amanda J.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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- Av lärosätet
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Lunds universitet
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Karolinska Institutet