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Effectiveness of Th...
Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study
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- Albshesh, Ahmad (author)
- Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Taylor, Joshua (author)
- Department of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
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- Savarino, Edoardo, V (author)
- Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
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- Truyens, Marie (author)
- IBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
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- Armuzzi, Alessandro (author)
- IBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
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- Ribaldone, Davide G. (author)
- Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy
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- Shitrit, Ariella Bar-Gil (author)
- Shaare Zedek Medical Center, Faculty of Medicine, Digestive Diseases Institute, Hebrew University of Jerusalem, Jerusalem, Israel
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- Fibelman, Morine (author)
- Tel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Molander, Pauliina (author)
- Abdominal Center, Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland
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- Liefferinckx, Claire (author)
- Department of Gastroenterology, Erasme University Hopital, Brussels, Belgium
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- Nancey, Stephane (author)
- Department of Gastroenterology, Hospices Civils de Lyon, University Claude Bernard Lyon, Lyon, France; INSERM, U1111, CIRI, Lyon, France
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- Korani, Mohamed (author)
- Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
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- Rutka, Mariann (author)
- First Department of Medicine, University of Szeged, Szeged, Hungary
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- Barreiro-de Acosta, Manuel (author)
- IBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
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- Domislovic, Viktor (author)
- Department of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
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- Suris, Gerard (author)
- Digestive System Service, Bellvitge University Hospital, Catalan Institute of Health, Barcelona, Spain
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- Eriksson, Carl, 1981- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
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- Alves, Catarina (author)
- Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
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- Mpitouli, Afroditi (author)
- Department of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
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- di Jiang, Caroline (author)
- Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
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- Tepes, Katja (author)
- University Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
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- Coletta, Marina (author)
- Department of Hepatology and Clinical Gastroenterology, ASST Santi Paolo e Carlo-Ospedale San Polo Universitario Milano Mariabeatrice, Milan, Italy
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- Foteinogiannopoulou, Kalliopi (author)
- Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
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- Gisbert, Javier P. (author)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
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- Amir-Barak, Hadar (author)
- IBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Attauabi, Mohamed (author)
- Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
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- Seidelin, Jakob (author)
- Department of Gastroenterology, Herlev University Hospital, Copenhagen, Denmark
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- Afif, Waqqas (author)
- Department of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
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- Marinelli, Carla (author)
- Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
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- Lobaton, Triana (author)
- IBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
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- Pugliese, Daniela (author)
- IBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
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- Maharshak, Nitsan (author)
- Tel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Cremer, Anneline (author)
- Department of Gastroenterology, Erasme University Hopital, Brussels, Belgium
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- Limdi, Jimmy K. (author)
- Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
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- Molnár, Tamás (author)
- First Department of Medicine, University of Szeged, Szeged, Hungary
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- Otero-Alvarin, Borja (author)
- IBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
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- Krznaric, Zeljko (author)
- Department of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
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- Magro, Fernando (author)
- Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
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- Karmiris, Konstantinos (author)
- Department of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
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- Raine, Tim (author)
- Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
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- Drobne, David (author)
- University Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
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- Koutroubakis, Ioannis (author)
- Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
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- Chaparro, Maria (author)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
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- Yanai, Henit (author)
- IBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Burisch, Johan (author)
- Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
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- Kopylov, Uri (author)
- Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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(creator_code:org_t)
- 2021-06-29
- 2021
- English.
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In: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:13
- Related links:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Crohn's disease
- anti-TNF failure
- treatment response
- treatment failure
- ustekinumab
- vedolizumab
Publication and Content Type
- ref (subject category)
- art (subject category)
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Albshesh, Ahmad
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Taylor, Joshua
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Savarino, Edoard ...
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Truyens, Marie
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Armuzzi, Alessan ...
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Ribaldone, David ...
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show more...
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Shitrit, Ariella ...
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Fibelman, Morine
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Molander, Paulii ...
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Liefferinckx, Cl ...
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Nancey, Stephane
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Korani, Mohamed
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Rutka, Mariann
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Barreiro-de Acos ...
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Domislovic, Vikt ...
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Suris, Gerard
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Eriksson, Carl, ...
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Alves, Catarina
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Mpitouli, Afrodi ...
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di Jiang, Caroli ...
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Tepes, Katja
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Coletta, Marina
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Foteinogiannopou ...
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Gisbert, Javier ...
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Amir-Barak, Hada ...
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Attauabi, Mohame ...
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Seidelin, Jakob
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Afif, Waqqas
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Marinelli, Carla
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Lobaton, Triana
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Pugliese, Daniel ...
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Maharshak, Nitsa ...
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Cremer, Anneline
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Limdi, Jimmy K.
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Molnár, Tamás
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Otero-Alvarin, B ...
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Krznaric, Zeljko
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Magro, Fernando
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Karmiris, Konsta ...
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Raine, Tim
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Drobne, David
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Koutroubakis, Io ...
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Chaparro, Maria
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Yanai, Henit
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Burisch, Johan
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Kopylov, Uri
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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Journal of Clini ...
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Örebro University