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SARS-CoV-2 Infectio...
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
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- Lugar, Marija (författare)
- Dresden University of Technology
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- Eugster, Anne (författare)
- Dresden University of Technology
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- Achenbach, Peter (författare)
- Helmholtz Zentrum München,Technical University of Munich
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- von dem Berge, Thekla (författare)
- Children's Hospital Auf der Bult
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- Berner, Reinhard (författare)
- University Clinic Carl Gustav Carus at the TU Dresden
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- Besser, Rachel E J (författare)
- Oxford University Hospital
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- Casteels, Kristina (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Elding Larsson, Helena (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
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- Gemulla, Gita (författare)
- University Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology
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- Kordonouri, Olga (författare)
- Children's Hospital Auf der Bult
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- Lindner, Annett (författare)
- Dresden University of Technology
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- Lundgren, Markus (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
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- Müller, Denise (författare)
- Dresden University of Technology
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- Oltarzewski, Mariusz (författare)
- National Research Institute of Mother and Child
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- Rochtus, Anne (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Scholz, Marlon (författare)
- Technical University of Munich,Helmholtz Zentrum München
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- Szypowska, Agnieszka (författare)
- Medical University of Warsaw
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- Todd, John A (författare)
- University of Oxford
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- Ziegler, Anette-Gabriele (författare)
- Technical University of Munich,Helmholtz Zentrum München
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- Bonifacio, Ezio (författare)
- University Clinic Carl Gustav Carus at the TU Dresden,Helmholtz Zentrum München,Dresden University of Technology
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(creator_code:org_t)
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- 2023
- 2023
- Engelska 10 s.
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Ingår i: JAMA. - 0098-7484. ; 330:12
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- IMPORTANCE: The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.OBJECTIVE: To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.DESIGN, SETTING, AND PARTICIPANTS: Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.EXPOSURE: SARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.MAIN OUTCOMES AND MEASURES: The development of multiple (≥2) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.RESULTS: Consent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).CONCLUSION AND RELEVANCE: In young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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JAMA
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Lugar, Marija
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Eugster, Anne
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Achenbach, Peter
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von dem Berge, T ...
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Berner, Reinhard
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Besser, Rachel E ...
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Casteels, Kristi ...
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Elding Larsson, ...
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Gemulla, Gita
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Kordonouri, Olga
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Lindner, Annett
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Lundgren, Markus
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Müller, Denise
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Oltarzewski, Mar ...
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Rochtus, Anne
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Scholz, Marlon
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Szypowska, Agnie ...
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Todd, John A
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Ziegler, Anette- ...
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Bonifacio, Ezio
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JAMA
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Lunds universitet