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Prediagnostic blood...
Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations
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- Baker, Jacqueline Roshelli (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Umesh, Sushma (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, Lyon, France
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- Schomburg, Lutz (författare)
- Institut für Experimentelle Endokrinologie, Charité Universitätsmedizin Berlin, Berlin, Germany
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Olsen, Anja (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Boutron-Ruault, Marie-Christine (författare)
- CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France
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- Rothwell, Joseph A. (författare)
- CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France
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- Severi, Gianluca (författare)
- CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Johnson, Theron (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany
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- Masala, Giovanna (författare)
- Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
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- Agnoli, Claudia (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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- Simeon, Vittorio (författare)
- Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania ‘Luigi Vanvitelli’, Naples, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Bueno-De-mesquita, H. Bas (författare)
- Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands
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- Gram, Inger Torhild (författare)
- Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (författare)
- Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway
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- Bonet, Catalina (författare)
- Unitat de Nutrició i Càncer, Malaga, Spain
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- Rodriguez-Barranco, Miguel (författare)
- Escuela Andaluza de Salud Pública (EASP), Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Houerta, José María (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
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- Gylling, Björn, 1978- (författare)
- Umeå universitet,Patologi
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- Van Guelpen, Bethany (författare)
- Umeå universitet,Onkologi
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Aglago, Elom (författare)
- International Agency for Research on Cancer, Lyon, France
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, Lyon, France
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, Lyon, France
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- Cross, Amanda J. (författare)
- School of Public Health, Imperial College London, London, United Kingdom
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- Heath, Alicia K. (författare)
- School of Public Health, Imperial College London, London, United Kingdom
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- Hughes, David J. (författare)
- Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
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- Fedirko, Veronika (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States
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(creator_code:org_t)
- 2021-10-22
- 2021
- Engelska.
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Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 9:11
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multi-variable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; Ptrend = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; Ptrend = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; Ptrend = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; Ptrend = 0.17) for overall mortal-ity. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cohort
- Colorectal cancer
- Selenium
- Selenoprotein P
- Survival
- Oncology
- onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Baker, Jacquelin ...
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Umesh, Sushma
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Jenab, Mazda
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Schomburg, Lutz
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Tjønneland, Anne
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Olsen, Anja
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visa fler...
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Boutron-Ruault, ...
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Rothwell, Joseph ...
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Severi, Gianluca
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Katzke, Verena
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Johnson, Theron
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Schulze, Matthia ...
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Masala, Giovanna
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Agnoli, Claudia
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Simeon, Vittorio
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Tumino, Rosario
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Bueno-De-mesquit ...
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Gram, Inger Torh ...
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Skeie, Guri
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Bonet, Catalina
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Rodriguez-Barran ...
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Houerta, José Ma ...
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Gylling, Björn, ...
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Van Guelpen, Bet ...
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Perez-Cornago, A ...
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Aglago, Elom
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Freisling, Heinz
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Weiderpass, Elis ...
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Cross, Amanda J.
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Heath, Alicia K.
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Hughes, David J.
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Fedirko, Veronik ...
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